Encukalner, also known as XEN1101, is a selective positive allosteric modulator of KCNQ2/3 (Kv7.2/7.3) voltage-gated potassium channels, which are critical regulators of neuronal excitability. It enhances M-current in neurons, thereby stabilizing the resting membrane potential and reducing neuronal firing. Preclinical electrophysiological studies demonstrated that Encukalner significantly increased potassium currents in cells expressing KCNQ2/3 channels with an EC₅₀ in the low micromolar range (~0.3–1 μM).
MedKoo Cat#: 145652
Name: Encukalner HCl
CAS#: Encukalner HCl
Chemical Formula: C23H30ClFN2O
Exact Mass: 368.2300
Molecular Weight: 404.95
Elemental Analysis: C, 68.22; H, 7.47; Cl, 8.75; F, 4.69; N, 6.92; O, 3.95
The following data is based on the product molecular weight 404.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
