TGN 073 is a facilitator of aquaporin-4 (AQP4), an astroglial water channel. The rats treated with TGN-073 showed the distribution of Gd-DTPA was more extensive and parenchymal uptake was higher compared with the vehicle group. Water diffusivity was increased in the brain of TGN-073 treated group, which indicates greater water flux. Also, MRI showed the glymphatic transport and distribution in the brain is naturally heterogeneous. TGN-073 can improve glymphatic function in the brain。
MedKoo Cat#: 128208
Name: TGN 073
CAS#: 877459-36-4
Chemical Formula: C18H16N2O3S
Exact Mass: 340.0882
Molecular Weight: 340.40
Elemental Analysis: C, 63.51; H, 4.74; N, 8.23; O, 14.10; S, 9.42
The following data is based on the product molecular weight 340.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
