ELQ334 | anti- parasite agent

MedKoo Cat#: 128172 | Name: ELQ-334

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ELQ334 is an anti- parasite agent.

Chemical Structure

ELQ-334

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128172

Name: ELQ-334

CAS#: N/A

Chemical Formula: C27H21F4NO6

Exact Mass: 531.1305

Molecular Weight: 531.46

Elemental Analysis: C, 61.02; H, 3.98; F, 14.30; N, 2.64; O, 18.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ELQ-334; ELQ334; ELQ 334

IUPAC/Chemical Name

7-((l6-oxidaneylidyne)methyl)-6-fluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4-yl ethyl carbonate

InChi Key

BWFPDACHFQZGLP-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H21F4NO6/c1-3-35-26(34)37-25-21-13-22(28)17(14-33)12-23(21)32-15(2)24(25)16-4-6-18(7-5-16)36-19-8-10-20(11-9-19)38-27(29,30)31/h4-13H,3H2,1-2,33H3

SMILES Code

CC1=NC2=CC(C#[OH3])=C(F)C=C2C(OC(OCC)=O)=C1C3=CC=C(OC4=CC=C(OC(F)(F)F)C=C4)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 531.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Anghel N, Imhof D, Winzer P, Balmer V, Ramseier J, Haenggeli K, Choi R, Hulverson MA, Whitman GR, Arnold SLM, Ojo KK, Van Voorhis WC, Doggett JS, Ortega-Mora LM, Hemphill A. Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. Int J Parasitol Drugs Drug Resist. 2021 Dec;17:92-106. doi: 10.1016/j.ijpddr.2021.08.007. Epub 2021 Aug 28. PMID: 34482255; PMCID: PMC8416643. 2: Lawres LA, Garg A, Kumar V, Bruzual I, Forquer IP, Renard I, Virji AZ, Boulard P, Rodriguez EX, Allen AJ, Pou S, Wegmann KW, Winter RW, Nilsen A, Mao J, Preston DA, Belperron AA, Bockenstedt LK, Hinrichs DJ, Riscoe MK, Doggett JS, Ben Mamoun C. Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone. J Exp Med. 2016 Jun 27;213(7):1307-18. doi: 10.1084/jem.20151519. Epub 2016 Jun 6. PMID: 27270894; PMCID: PMC4925016. 3: Martynowicz J, Doggett JS, Sullivan WJ Jr. Efficacy of Guanabenz Combination Therapy against Chronic Toxoplasmosis across Multiple Mouse Strains. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00539-20. doi: 10.1128/AAC.00539-20. PMID: 32540979; PMCID: PMC7449173. 4: Anghel N, Balmer V, Müller J, Winzer P, Aguado-Martinez A, Roozbehani M, Pou S, Nilsen A, Riscoe M, Doggett JS, Hemphill A. Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice. Front Vet Sci. 2018 Nov 19;5:285. doi: 10.3389/fvets.2018.00285. PMID: 30510935; PMCID: PMC6252379.