MedKoo Cat#: 565247 | Name: FPL64176
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

FPL64176 is a potent L-type Ca2+ channel activator.

Chemical Structure

FPL64176
FPL64176
CAS#120934-96-5

Theoretical Analysis

MedKoo Cat#: 565247

Name: FPL64176

CAS#: 120934-96-5

Chemical Formula: C22H21NO3

Exact Mass: 347.1521

Molecular Weight: 347.41

Elemental Analysis: C, 76.06; H, 6.09; N, 4.03; O, 13.82

Price and Availability

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5mg USD 350.00 2 Weeks
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Related CAS #
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Synonym
FPL-64176; FPL 64176; FPL64176
IUPAC/Chemical Name
Methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate
InChi Key
MDMWHKZANMNXTF-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3
SMILES Code
O=C(C1=C(C)NC(C)=C1C(C2=CC=CC=C2CC3=CC=CC=C3)=O)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhong W, Chebolu S, Darmani NA. Intracellular emetic signaling evoked by the L-type Ca(2+) channel agonist FPL64176 in the least shrew (Cryptotis parva). Eur J Pharmacol. 2018 Sep 5;834:157-168. doi: 10.1016/j.ejphar.2018.06.035. Epub 2018 Jun 30. PubMed PMID: 29966616; PubMed Central PMCID: PMC6104632. 2: Marom M, Hagalili Y, Sebag A, Tzvier L, Atlas D. Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. J Biol Chem. 2010 Mar 5;285(10):6996-7005. doi: 10.1074/jbc.M109.059865. Epub 2010 Jan 6. PubMed PMID: 20054004; PubMed Central PMCID: PMC2844149. 3: Cheng HC, Incardona J. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):174-84. doi: 10.1016/j.vascn.2009.05.010. Epub 2009 Jun 11. PubMed PMID: 19524054.