HFN-71940 | CAS#1189871-94-0 | Nitrososarcosine internal standard

MedKoo Cat#: 465283 | Name: HFN-71940

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HFN-71940 is intended for use as an internal standard for the quantification of nitrososarcosine by GC- or LC-MS. N-Nitrososarcosine is a nitrosamine. It has been found in smoked and cured meats and tobacco smoke. Dietary administration of N-nitrososarcosine (0.25%) induces tumors in mice and administration via the drinking water at doses of 100 or 200 mg/kg induces tumors in rats. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

HFN-71940

CAS#1189871-94-0

Theoretical Analysis

MedKoo Cat#: 465283

Name: HFN-71940

CAS#: 1189871-94-0

Chemical Formula: C3H3D3N2O3

Exact Mass: 121.0567

Molecular Weight: 121.11

Elemental Analysis: C, 29.75; H, 7.49; N, 23.13; O, 39.63

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 285.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

HFN-71940; HFN71940; HFN 71940; N-Nitrososarcosine-d3; N-Nitrososarcosine d3;

IUPAC/Chemical Name

N-(methyl-d3)-N-nitrosoglycine

InChi Key

HJMPSKKJHVWPBK-FIBGUPNXSA-N

InChi Code

InChI=1S/C3H6N2O3/c1-5(4-8)2-3(6)7/h2H2,1H3,(H,6,7)/i1D3

SMILES Code

OC(CN(N=O)C([2H])([2H])[2H])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 121.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B. Amended Safety Assessment of Fatty Acyl Sarcosines and Sarcosinate Salts as Used in Cosmetics. Int J Toxicol. 2021 Jul 6:10915818211023881. doi: 10.1177/10915818211023881. Epub ahead of print. PMID: 34225481. 2: Werneth M, Pani J, Hofbauer L, Pummer S, Weber MT, Pour G, Kählig H, Mayer- Helm B, Stepan H. Stereospecific Response of E/Z-isomers of N-Nitrososarcosine in LC-ESI-MS/MS. J Chromatogr Sci. 2021 Feb 23:bmab013. doi: 10.1093/chromsci/bmab013. Epub ahead of print. PMID: 33618358. 3: Shubin AV, Lesovaya EA, Kirsanov KI, Antoshina EE, Trukhanova LS, Gorkova TG, Belitsky GA, Yakubovskaya MG, Demidyuk IV. Re-Examination of the Esophageal Squamous Cell Carcinoma Model in Rats Induced by N-Nitrososarcosine Ethyl Ester Precursors. Bull Exp Biol Med. 2018 Mar;164(5):676-679. doi: 10.1007/s10517-018-4057-2. Epub 2018 Mar 26. PMID: 29577190. 4: National Toxicology Program. N-Nitrosamines (15 listings): N-Nitrososarcosine. Rep Carcinog. 2011;12:324. PMID: 21860517. 5: Cheng G, Wang M, Villalta PW, Hecht SS. Detection of 7-(2'-carboxyethyl)guanine but not 7-carboxymethylguanine in human liver DNA. Chem Res Toxicol. 2010 Jun 21;23(6):1089-96. doi: 10.1021/tx100062v. PMID: 20438065; PMCID: PMC3230219. 6: Derave W, Vanden Eede E, Hespel P, Carmella SG, Hecht SS. Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine. Nutrition. 2006 Mar;22(3):332-3. doi: 10.1016/j.nut.2005.10.004. Epub 2006 Jan 18. PMID: 16413752. 7: National Toxicology Program. N-Nitrososarcosine. Rep Carcinog. 2002;10:188-9. Update in: Rep Carcinog. 2004;11:III208. PMID: 15328587. 8: N-Nitrososarcosine. Rep Carcinog. 2004;11:III208. PMID: 21089938. 9: Wang DY, Xiang YY, Li XJ, Hashimoto M, Tanaka M, Sugimura H. Mxi1 is a potential cellular target of carcinogens and frequently mutated in experimental rat tumors and tumor cell lines. Pathol Int. 2000 May;50(5):373-83. doi: 10.1046/j.1440-1827.2000.01057.x. PMID: 10849326. 10: Cheng CF, Tsang CW. Separation of N-nitrosoamino acids by C18 reversed-phase ion-pair high-performance liquid chromatography and compatible detection by electrospray ionization mass spectrometry. J Chromatogr A. 1999 Jul 23;849(2):389-402. doi: 10.1016/s0021-9673(99)00610-x. PMID: 10457437. 11: Tricker AR. N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. Eur J Cancer Prev. 1997 Jun;6(3):226-68. PMID: 9306073. 12: Wang DY, Xiang YY, Tanaka M, Shen Q, Sugimura H. Identification of cytokeratin subspecies altered in rat experimental esophageal tumors by subtractive cloning. Cancer Lett. 1996 Nov 12;108(1):119-27. doi: 10.1016/s0304-3835(96)04403-5. PMID: 8950218.