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MedKoo Cat#: 145615 | Name: Isoplumbagin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoplumbagin is a naturally occurring quinone from Lawsonia inermis and Plumbago europaea. ISOPLUMBAGIN is reported to have anti-inflammatory and antimicrobial activity.

Chemical Structure

Isoplumbagin
Isoplumbagin
CAS#14777-17-4

Theoretical Analysis

MedKoo Cat#: 145615

Name: Isoplumbagin

CAS#: 14777-17-4

Chemical Formula: C11H8O3

Exact Mass: 188.0500

Molecular Weight: 188.18

Elemental Analysis: C, 70.21; H, 4.29; O, 25.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Isoplumbagin;
IUPAC/Chemical Name
8-hydroxy-2-methylnaphthalene-1,4-dione
InChi Key
ZMOIGGHUSNHCAB-UHFFFAOYSA-N
InChi Code
1S/C11H8O3/c1-6-5-9(13)7-3-2-4-8(12)10(7)11(6)14/h2-5,12H,1H3
SMILES Code
CC1=CC(=O)C2=CC=CC(O)=C2C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 188.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tsao YC, Chang YJ, Wang CH, Chen L. Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone. Int J Mol Sci. 2020 Jun 19;21(12):4378. doi: 10.3390/ijms21124378. PMID: 32575541; PMCID: PMC7352187. 2: Chen L, Cho HY, Chuang TH, Ke TL, Wu SN. The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis of erg-mediated K+ Currents. Biomedicines. 2022 Mar 27;10(4):780. doi: 10.3390/biomedicines10040780. PMID: 35453530; PMCID: PMC9029050. 3: Wu SN, Wu CL, Cho HY, Chiang CW. Effective Perturbations by Small-Molecule Modulators on Voltage-Dependent Hysteresis of Transmembrane Ionic Currents. Int J Mol Sci. 2022 Aug 21;23(16):9453. doi: 10.3390/ijms23169453. PMID: 36012718; PMCID: PMC9408818. 4: Sobhani M, Abbas-Mohammadi M, Ebrahimi SN, Aliahmadi A. Tracking leading anti-Candida compounds in plant samples; Plumbago europaea. Iran J Microbiol. 2018 Jun;10(3):187-193. PMID: 30112157; PMCID: PMC6087695. 5: An X, Li T, Hu J, Li Y, Liu H, Fang H, Wei X. Evaluation of physicochemical characteristics, bioactivity, flavor profile and key metabolites in the fermentation of goji juice by Lacticaseibacillus rhamnosus. Food Chem X. 2024 Aug 22;23:101755. doi: 10.1016/j.fochx.2024.101755. PMID: 39257492; PMCID: PMC11386055.