Synonym
GS-2278; GS2278; GS 2278
IUPAC/Chemical Name
(R)-1-(2,5-difluoropyridin-3-yl)ethyl (1-methyl-4-(5-(2-(trifluoromethyl)pyrimidine-5-carboxamido)pyridin-2-yl)-1H-1,2,3-triazol-5-yl)carbamate
InChi Key
VHSVUMBZCLBMNY-SNVBAGLBSA-N
InChi Code
InChI=1S/C22H16F5N9O3/c1-10(14-5-12(23)8-29-17(14)24)39-21(38)33-18-16(34-35-36(18)2)15-4-3-13(9-28-15)32-19(37)11-6-30-20(31-7-11)22(25,26)27/h3-10H,1-2H3,(H,32,37)(H,33,38)/t10-/m1/s1
SMILES Code
FC(F)(F)C1=NC=C(C(NC2=CN=C(C3=C(NC(O[C@H](C)C4=C(F)N=CC(F)=C4)=O)N(C)N=N3)C=C2)=O)C=N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
549.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Tang DT, Du Z, Yang KS, Bestvater BP, Kaplan J, Neubig ME, Olen CL, Phillips B, Wang P, Hudson T, Marchand B, Chan J, Sharma M, Hu Y, Matles M, Nejati E, Chojnacka M, Adams C, Pong C, Holsapple K, Budas G, Tsui V, Venkataramani C, Lazerwith SE, Notte GT, Watkins WJ, McGlinchey E, Zagorska A, Farand J. Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2024 Nov 21. doi: 10.1021/acs.jmedchem.4c02090. Epub ahead of print. PMID: 39570661.
