Chlorzolamide | CAS#5541-92-4 | sulfonamide-based inhibitor

MedKoo Cat#: 145594 | Name: Chlorzolamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorzolamide is a sulfonamide-based inhibitor. CHLORZOLAMIDE appears to be cytotoxic to prostate cancer cells.

Chemical Structure

Chlorzolamide

CAS#5541-92-4

Theoretical Analysis

MedKoo Cat#: 145594

Name: Chlorzolamide

CAS#: 5541-92-4

Chemical Formula: C8H6ClN3O2S2

Exact Mass: 274.9600

Molecular Weight: 275.73

Elemental Analysis: C, 34.85; H, 2.19; Cl, 12.86; N, 15.24; O, 11.61; S, 23.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Chlorzolamide;

IUPAC/Chemical Name

5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide

InChi Key

PZVGOWIIHCUHAO-UHFFFAOYSA-N

InChi Code

1S/C8H6ClN3O2S2/c9-6-4-2-1-3-5(6)7-11-12-8(15-7)16(10,13)14/h1-4H,(H2,10,13,14)

SMILES Code

NS(=O)(=O)C1=NN=C(S1)C2=CC=CC=C2Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 275.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Geers C, Gros G. Effects of carbonic anhydrase inhibitors on contraction, intracellular pH and energy-rich phosphates of rat skeletal muscle. J Physiol. 1990 Apr;423:279-97. doi: 10.1113/jphysiol.1990.sp018022. PMID: 2388152; PMCID: PMC1189757. 2: Genis C, Sippel KH, Case N, Cao W, Avvaru BS, Tartaglia LJ, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Rosser CJ, McKenna R. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry. 2009 Feb 17;48(6):1322-31. doi: 10.1021/bi802035f. PMID: 19170619; PMCID: PMC2713499. 3: Tu CK, Thomas HG, Wynns GC, Silverman DN. Hydrolysis of 4-nitrophenyl acetate catalyzed by carbonic anhydrase III from bovine skeletal muscle. J Biol Chem. 1986 Aug 5;261(22):10100-3. PMID: 3090030. 4: Kararli T, Silverman DN. Inhibition of the hydration of CO2 catalyzed by carbonic anhydrase III from cat muscle. J Biol Chem. 1985 Mar 25;260(6):3484-9. PMID: 3919025. 5: Wetzel P, Gros G. Sarcolemmal carbonic anhydrase in red and white rabbit skeletal muscle. Arch Biochem Biophys. 1990 Jun;279(2):345-54. doi: 10.1016/0003-9861(90)90501-o. PMID: 2112370. 6: Wetzel P, Liebner T, Gros G. Carbonic anhydrase inhibition and calcium transients in soleus fibers. FEBS Lett. 1990 Jul 2;267(1):66-70. doi: 10.1016/0014-5793(90)80289-u. PMID: 2114323. 7: Wetzel P, Gros G. Inhibition and kinetic properties of membrane-bound carbonic anhydrases in rabbit skeletal muscles. Arch Biochem Biophys. 1998 Aug 15;356(2):151-8. doi: 10.1006/abbi.1998.0762. PMID: 9705205. 8: Wetzel P, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres. Pflugers Arch. 2002 Mar;443(5-6):762-70. doi: 10.1007/s00424-001-0777-6. Epub 2002 Jan 22. PMID: 11889574. 9: Wetzel P, Kleinke T, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase slows the Ca(2+) transient in rat skeletal muscle fibers. Am J Physiol Cell Physiol. 2002 Oct;283(4):C1242-53. doi: 10.1152/ajpcell.00106.2002. PMID: 12225987. 10: Wetzel P, Hasse A, Papadopoulos S, Voipio J, Kaila K, Gros G. Extracellular carbonic anhydrase activity facilitates lactic acid transport in rat skeletal muscle fibres. J Physiol. 2001 Mar 15;531(Pt 3):743-56. doi: 10.1111/j.1469-7793.2001.0743h.x. PMID: 11251055; PMCID: PMC2278498. 11: Henry RP, Bilger SM, Moss AG. Carbonic anhydrase isozyme distribution and characterization in metabolic fiber types of the dorsal levator muscle of the blue crab, Callinectes sapidus. J Exp Zool. 2001 Aug 1;290(3):234-46. doi: 10.1002/jez.1054. PMID: 11479903. 12: Geers C, Benz K, Gros G. Effects of carbonic anhydrase inhibitors on oxygen consumption and lactate accumulation in skeletal muscle. Comp Biochem Physiol A Physiol. 1995 Sep;112(1):111-7. doi: 10.1016/0300-9629(95)90853-n. PMID: 7553327. 13: Geers C, Gros G. Carbonic anhydrase inhibition affects contraction of directly stimulated rat soleus. Life Sci. 1988;42(1):37-45. doi: 10.1016/0024-3205(88)90622-4. PMID: 3336271. 14: Sanyal G. The carbon dioxide hydration activity of the sulfonamide-resistant carbonic anhydrase from the liver of male rat: pH independence of the steady- state kinetics. Arch Biochem Biophys. 1984 Nov 1;234(2):576-9. doi: 10.1016/0003-9861(84)90306-0. PMID: 6437333. 15: Geers C, Gros G. Contractile function of papillary muscles with carbonic anhydrase inhibitors. Life Sci. 1995;57(6):591-7. doi: 10.1016/0024-3205(95)00309-t. PMID: 7623626.