Chlorquinox | CAS#3495-42-9

MedKoo Cat#: 527923 | Name: Chlorquinox

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorquinox is a Fungicide, Bactericide, Wood Preservative.

Chemical Structure

Chlorquinox

CAS#3495-42-9

Theoretical Analysis

MedKoo Cat#: 527923

Name: Chlorquinox

CAS#: 3495-42-9

Chemical Formula: C8H2Cl4N2

Exact Mass: 265.8972

Molecular Weight: 267.92

Elemental Analysis: C, 35.86; H, 0.75; Cl, 52.93; N, 10.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Chlorquinox; NC 1978; NC-1978; NC1978;

IUPAC/Chemical Name

5,6,7,8-Tetrachloroquinoxaline

InChi Key

NHTGQOXRZFUGJX-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H2Cl4N2/c9-3-4(10)6(12)8-7(5(3)11)13-1-2-14-8/h1-2H

SMILES Code

ClC1=C2N=CC=NC2=C(Cl)C(Cl)=C1Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 267.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Antony HA, Topno NS, Gummadi SN, Sankar DS, Krishna R, Parija SC. In silico modeling of Plasmodium falciparum chloroquine resistance transporter protein and biochemical studies suggest its key contribution to chloroquine resistance. Acta Trop. 2018 Oct 8. pii: S0001-706X(18)30439-X. doi: 10.1016/j.actatropica.2018.10.001. [Epub ahead of print] PubMed PMID: 30308208. 2: Yong X, Yang X, Emory SR, Wang J, Dai J, Yu X, Mei L, Xie J, Ruan G. A potent, minimally invasive and simple strategy of enhancing intracellular targeted delivery of Tat peptide-conjugated quantum dots: organic solvent-based permeation enhancer. Biomater Sci. 2018 Oct 10. doi: 10.1039/c8bm00928g. [Epub ahead of print] PubMed PMID: 30303500. 3: Gontijo DC, Brandão GC, Nascimento MFAD, Oliveira AB. Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS. J Pharm Pharmacol. 2018 Oct 10. doi: 10.1111/jphp.13029. [Epub ahead of print] PubMed PMID: 30303245. 4: Wang X, Shen C, Liu Z, Peng F, Chen X, Yang G, Zhang D, Yin Z, Ma J, Zheng Z, Zhao B, Liu H, Wang L, Wu J, Han D, Wang K, Zhong C, Hou X, Zhao W, Shu M, Wang X, Zhao S. Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma. Cell Death Dis. 2018 Oct 9;9(10):1032. doi: 10.1038/s41419-018-1058-z. PubMed PMID: 30302016. 5: Feng H, Cheng X, Kuang J, Chen L, Yuen S, Shi M, Liang J, Shen B, Jin Z, Yan J, Qiu W. Apatinib-induced protective autophagy and apoptosis through the AKT-mTOR pathway in anaplastic thyroid cancer. Cell Death Dis. 2018 Oct 9;9(10):1030. doi: 10.1038/s41419-018-1054-3. PubMed PMID: 30301881. 6: Delpe Acharige AMDS, Brennan MPC, Lauder K, McMahon F, Odebunmi AO, Durrant MC. Computational insights into the inhibition of β-haematin crystallization by antimalarial drugs. Dalton Trans. 2018 Oct 9. doi: 10.1039/c8dt03369b. [Epub ahead of print] PubMed PMID: 30298161. 7: L'abbate FP, Müller R, Openshaw R, Combrinck JM, de Villiers KA, Hunter R, Egan TJ. Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites. Eur J Med Chem. 2018 Sep 28;159:243-254. doi: 10.1016/j.ejmech.2018.09.060. [Epub ahead of print] PubMed PMID: 30296683. 8: Aye T, Arndt PA. Utility of chloroquine diphosphate in the blood bank laboratory. Immunohematology. 2018 Sep;34(3):98-102. PubMed PMID: 30295504. 9: Chen T, Li XF, Wang JF, Zhou S, Fang F. [Effects of Luteolin on Proliferation and Programmed Cell Death of Human Multiple Myeloma Cell RPMI-8226]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Oct;26(5):1425-1429. doi: 10.7534/j.issn.1009-2137.2018.05.028. Chinese. PubMed PMID: 30295262. 10: Finsterer J, Melichart-Kotig M, Woehrer A. Mitochondrial disorder mimicking rheumatoid disease. Z Rheumatol. 2018 Oct 5. doi: 10.1007/s00393-018-0551-1. [Epub ahead of print] PubMed PMID: 30291434. 11: Tavul L, Hetzel MW, Teliki A, Walsh D, Kiniboro B, Rare L, Pulford J, Siba PM, Karl S, Makita L, Robinson L, Kattenberg JH, Laman M, Oswyn G, Mueller I. Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Papua New Guinea. Malar J. 2018 Oct 5;17(1):350. doi: 10.1186/s12936-018-2494-z. PubMed PMID: 30290825. 12: Qian G, Liu D, Hou L, Hamid M, Chen X, Gan F, Huang K. Ochratoxin A induces cytoprotective autophagy via blocking AKT/mTOR signaling pathway in PK-15 cells. Food Chem Toxicol. 2018 Oct 1. pii: S0278-6915(18)30714-2. doi: 10.1016/j.fct.2018.09.070. [Epub ahead of print] PubMed PMID: 30287338. 13: Abreha T, Hwang J, Thriemer K, Tadesse Y, Girma S, Melaku Z, Assef A, Kassa M, Chatfield MD, Landman KZ, Chenet SM, Lucchi NW, Udhayakumar V, Zhou Z, Shi YP, Kachur SP, Jima D, Kebede A, Solomon H, Mekasha A, Alemayehu BH, Malone JL, Dissanayake G, Teka H, Auburn S, Seidlein LV, Price RN. Correction: Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax infection in Ethiopia: A randomized controlled trial. PLoS Med. 2018 Oct 4;15(10):e1002677. doi: 10.1371/journal.pmed.1002677. eCollection 2018 Oct. PubMed PMID: 30286081. 14: Arya BD, Mittal S, Joshi P, Pandey AK, Ramirez-Vick JE, Singh SP. Graphene oxide-chloroquine nanoconjugate induce necroptotic death in A549 cancer cells through autophagy modulation. Nanomedicine (Lond). 2018 Oct 4. doi: 10.2217/nnm-2018-0086. [Epub ahead of print] PubMed PMID: 30284495. 15: Li X, Lee Y, Kang Y, Dai B, Perez MR, Pratt M, Koay EJ, Kim M, Brekken RA, Fleming JB. Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. Cell Death Differ. 2018 Oct 3. doi: 10.1038/s41418-018-0207-3. [Epub ahead of print] PubMed PMID: 30283082. 16: Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, Birnbaumer L, Liao Y. Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 2018 Oct 3;9(10):1015. doi: 10.1038/s41419-018-1052-5. PubMed PMID: 30282964; PubMed Central PMCID: PMC6170481. 17: Hwang S, Mruk K, Rahighi S, Raub AG, Chen CH, Dorn LE, Horikoshi N, Wakatsuki S, Chen JK, Mochly-Rosen D. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nat Commun. 2018 Oct 2;9(1):4045. doi: 10.1038/s41467-018-06447-z. PubMed PMID: 30279493; PubMed Central PMCID: PMC6168459. 18: Yuan X, Bhat O, Meng N, Lohner H, Li PL. Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries. Am J Pathol. 2018 Sep 28. pii: S0002-9440(18)30308-0. doi: 10.1016/j.ajpath.2018.08.014. [Epub ahead of print] PubMed PMID: 30273598. 19: Zhao Z, Xia G, Li N, Su R, Chen X, Zhong L. Autophagy Inhibition Promotes Bevacizumab-induced Apoptosis and Proliferation Inhibition in Colorectal Cancer Cells. J Cancer. 2018 Sep 8;9(18):3407-3416. doi: 10.7150/jca.24201. eCollection 2018. PubMed PMID: 30271503; PubMed Central PMCID: PMC6160673. 20: Warrasak S, Euswas A, Fukuda MM, Ittiverakul M, Miller RS, Krudsood S, Ohrt C. Comparative ophthalmic assessment of patients receiving tafenoquine or chloroquine/primaquine in a randomized clinical trial for Plasmodium vivax malaria radical cure. Int Ophthalmol. 2018 Sep 29. doi: 10.1007/s10792-018-1003-2. [Epub ahead of print] PubMed PMID: 30269312.