BBT-176 | EGFR inhibitor

MedKoo Cat#: 128136 | Name: BBT-176

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BBT-176 is a EGFR inhibitor

Chemical Structure

BBT-176

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128136

Name: BBT-176

CAS#: N/A

Chemical Formula: C30H41ClN8O3S

Exact Mass: 628.2711

Molecular Weight: 629.22

Elemental Analysis: C, 57.27; H, 6.57; Cl, 5.63; N, 17.81; O, 7.63; S, 5.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BBT176; BBT-176; BBT 176

IUPAC/Chemical Name

N-(2-((5-chloro-2-((2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylmethanesulfonamide

InChi Key

CXTOGTLIIUTLRJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H41ClN8O3S/c1-21-18-25(28(42-4)19-27(21)39-12-10-22(11-13-39)38-16-14-36(2)15-17-38)34-30-32-20-23(31)29(35-30)33-24-8-6-7-9-26(24)37(3)43(5,40)41/h6-9,18-20,22H,10-17H2,1-5H3,(H2,32,33,34,35)

SMILES Code

ClC1=C(NC2=CC=CC=C2N(C)S(=O)(C)=O)N=C(NC3=CC(C)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3OC)N=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 629.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lim SM, Fujino T, Kim C, Lee G, Lee YH, Kim DW, Ahn JS, Mitsudomi T, Jin T, Lee SY. BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non-Small Cell Lung Cancer. Clin Cancer Res. 2023 Aug 15;29(16):3004-3016. doi: 10.1158/1078-0432.CCR-22-3901. PMID: 37249619; PMCID: PMC10425724. 2: Laface C, Fedele P. What the future holds: BBT-176, beyond third-generation EGFR tyrosine kinase inhibitors. Transl Lung Cancer Res. 2024 Feb 29;13(2):220-222. doi: 10.21037/tlcr-23-795. Epub 2024 Feb 27. PMID: 38496697; PMCID: PMC10938097.