R-348 | JAK3- | Syk- | inhibitor | CAS#916742-11-5

MedKoo Cat#: 125180 | Name: R-348

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R-348 is a JAK3- and Syk-inhibitor.

Chemical Structure

R-348

CAS#916742-11-5

Theoretical Analysis

MedKoo Cat#: 125180

Name: R-348

CAS#: 916742-11-5

Chemical Formula: C23H22FN5O4S

Exact Mass: 483.1400

Molecular Weight: 483.52

Elemental Analysis: C, 57.13; H, 4.59; F, 3.93; N, 14.48; O, 13.24; S, 6.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JAK-IN-11; 916742-11-5; R-348; 3J396119JY

IUPAC/Chemical Name

N-((5-((5-fluoro-4-((4-(prop-2-yn-1-yloxy)phenyl)amino)pyrimidin-2-yl)amino)-2-methylphenyl)sulfonyl)propionamide

InChi Key

IGLNXKVGKIFNBQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H22FN5O4S/c1-4-12-33-18-10-8-16(9-11-18)26-22-19(24)14-25-23(28-22)27-17-7-6-15(3)20(13-17)34(31,32)29-21(30)5-2/h1,6-11,13-14H,5,12H2,2-3H3,(H,29,30)(H2,25,26,27,28)

SMILES Code

CCC(=O)NS(=O)(=O)C1=CC(NC2=NC(NC3=CC=C(OCC#C)C=C3)=C(F)C=N2)=CC=C1C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 483.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85(6):885-92. doi: 10.1097/TP.0b013e318166acc4. PMID: 18360272.