Synonym
GS8873; GS 8873; GS-8873
IUPAC/Chemical Name
(R)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-oxo-2,3,8,13b-tetrahydro-1H-pyrido[2,1-a]pyrrolo[1,2-c]phthalazine-7-carboxylic acid
InChi Key
DJTSTEHRSYEORJ-LJQANCHMSA-N
InChi Code
InChI=1S/C24H30N2O6/c1-24(2)7-6-19-17-11-22(32-9-5-8-30-3)15(14-31-4)10-16(17)20-12-21(27)18(23(28)29)13-25(20)26(19)24/h10-13,19H,5-9,14H2,1-4H3,(H,28,29)/t19-/m1/s1
SMILES Code
COCC1=C(OCCCOC)C=C([C@]2([H])N(C(C)(CC2)C)N3C4=CC(C(C(O)=O)=C3)=O)C4=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
442.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kato D, Choy RW, Canales E, Dick RA, Lake AD, Shapiro ND, Chin E, Li J, Zhang
JR, Wu Q, Saito RD, Metobo S, Aktoudianakis E, Schroeder SD, Yang ZY, Glatt DM,
Balsitis S, Gamelin L, Yu M, Cheng G, Delaney WE 4th, Link JO. Discovery of
Hepatitis B Virus Surface Antigen Suppressor GS-8873. ACS Med Chem Lett. 2024
Mar 22;15(4):546-554. doi: 10.1021/acsmedchemlett.4c00037. PMID: 38628802;
PMCID: PMC11017420.
2: Lake AD, Holsapple K, McDonnell T, Arezzo JC, Ramirez R, Gamelin L, Yu M,
Glatt D, Dick R, Xie X, Choy R, Cheng G, Tay CH, Chester A, Kato D, Burns-Naas
LA. Neurotoxicity of an Hepatitis B Virus (HBV) Transcript Inhibitor in 13-Week
Rat and Monkey Studies. Toxicol Sci. 2022 Mar 28;186(2):298-308. doi:
10.1093/toxsci/kfac009. PMID: 35134235.
