AZ1992 is a highly potent and selective CDK12 inhibitor with IC50 = 491 nM. AZ1992 has CAS#2220184-50-7, which was reported in Johannes JW et al's recent paper ChemMedChem. 2018 Feb 6;13(3):231-235 (compound 7). AZ1992 showed 5-fold CDK2 and near 20-fold CDK9 selectivity. AZ1992 was profiled across a panel of 352 kinases at 0.1 mm followed by concentration–response testing in 30 of the top hits, showing that AZ1992 is a highly selective CDK12 inhibitor, and this result was confirmed by affinity proteomics using a kinase affinity matrix.
MedKoo Cat#: 407945
Name: AZ1992
CAS#: 2220184-50-7
Chemical Formula: C23H28F2N8O
Exact Mass: 470.2354
Molecular Weight: 470.53
Elemental Analysis: C, 58.71; H, 6.00; F, 8.08; N, 23.81; O, 3.40
The following data is based on the product molecular weight 470.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
