AB-161 is PAPD5/7 inhibitor (HBsAg EC50 = 2.2 nM). AB-161 showed similarly potent to AB-452 in vitro and in vivo but showed dramatically higher rodent liver-to-plasma ratios. There were no neurobehavioral effects with AB-161 in dogs up to 45 mg/kg after 60 days, unlike with AB-452, where these were observed at lower doses by day 14.
MedKoo Cat#: 128115
Name: AB-161
CAS#: N/A
Chemical Formula: C21H21F2N3O5
Exact Mass: 433.1449
Molecular Weight: 433.41
Elemental Analysis: C, 58.20; H, 4.88; F, 8.77; N, 9.70; O, 18.46
The following data is based on the product molecular weight 433.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
