MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 128088 | Name: Mebhydroline
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mebhydroline acts as a selective antagonist of farnesoid X receptor (FXR).

Chemical Structure

Mebhydroline
Mebhydroline
CAS#524-81-2 (free base)

Theoretical Analysis

MedKoo Cat#: 128088

Name: Mebhydroline

CAS#: 524-81-2 (free base)

Chemical Formula: C19H20N2

Exact Mass: 276.1626

Molecular Weight: 276.38

Elemental Analysis: C, 82.57; H, 7.29; N, 10.14

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
6153-33-9 (napadisylate) 524-81-2 (free base)
Synonym
Mebhydroline; Mebhydrolin
IUPAC/Chemical Name
5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
InChi Key
FQQIIPAOSKSOJM-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
SMILES Code
CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 276.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McEwen J, Strickland WJ. Mebhydrolin napadisylate. A possible cause of reversible agranulocytosis and neutropenia. Med J Aust. 1982 Nov 27;2(11):523-5. PMID: 6130466. 2: Edoute Y, Nagler A, Brenner B. [Agranulocytosis associated with mebhydrolin napadisylate (Incidal)]. Harefuah. 1984 Mar 1;106(5):208-9. Hebrew. PMID: 6724409. 3: Li Z, Ye CY, Zhao TY, Yang L. Model of genetic and environmental factors associated with type 2 diabetes mellitus in a Chinese Han population. BMC Public Health. 2020 Jun 29;20(1):1024. doi: 10.1186/s12889-020-09130-5. PMID: 32600448; PMCID: PMC7325035. 4: Stoop D, Vercammen L, Polyzos NP, de Vos M, Nekkebroeck J, Devroey P. Effect of ovarian stimulation and oocyte retrieval on reproductive outcome in oocyte donors. Fertil Steril. 2012 Jun;97(6):1328-30. doi: 10.1016/j.fertnstert.2012.03.012. Epub 2012 Mar 30. PMID: 22464081. 5: Bello AI, Quartey JN, Appiah LA. Screening for developmental delay among children attending a rural community welfare clinic in Ghana. BMC Pediatr. 2013 Aug 13;13:119. doi: 10.1186/1471-2431-13-119. PMID: 23937954; PMCID: PMC3751115. 6: Nakagawa H, Fujiwara N, Tateishi R, Arano T, Nakagomi R, Kondo M, Minami T, Sato M, Uchino K, Enooku K, Asaoka Y, Kondo Y, Shiina S, Yoshida H, Koike K. Impact of serum levels of interleukin-6 and adiponectin on all-cause, liver- related, and liver-unrelated mortality in chronic hepatitis C patients. J Gastroenterol Hepatol. 2015 Feb;30(2):379-88. doi: 10.1111/jgh.12719. PMID: 25168107. 7: Lee YC, Lin CH, Lin MS, Lin JW, Chang CH, Lai MS. Effects of selective serotonin reuptake inhibitors versus tricyclic antidepressants on cerebrovascular events: a nationwide population-based cohort study. J Clin Psychopharmacol. 2013 Dec;33(6):782-9. doi: 10.1097/JCP.0b013e31829c970e. PMID: 24091857. 8: Wu B, Wang HL, Cee VJ, Lanman BA, Nixey T, Pettus L, Reed AB, Wurz RP, Guerrero N, Sastri C, Winston J, Lipford JR, Lee MR, Mohr C, Andrews KL, Tasker AS. Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorg Med Chem Lett. 2015 Feb 15;25(4):775-80. doi: 10.1016/j.bmcl.2014.12.091. Epub 2015 Jan 7. PMID: 25616902. 9: KHARKEVICH DA. K farmakologii diazolina [Pharmacology of diazoline]. Farmakol Toksikol. 1957 Nov-Dec;20(6):46-51. Russian. PMID: 13562138. 10: Verstraete E, Boelens J, De Coen K, Claeys G, Vogelaers D, Vanhaesebrouck P, Blot S. Healthcare-associated bloodstream infections in a neonatal intensive care unit over a 20-year period (1992-2011): trends in incidence, pathogens, and mortality. Infect Control Hosp Epidemiol. 2014 May;35(5):511-8. doi: 10.1086/675836. Epub 2014 Mar 17. PMID: 24709719.

View History

N-1149 HCl

N-1149 HCl