SR-16584 is an antagonist of the α3β4 nAChR subtype (IC50 = 10.2 μM).The compound exhibits high affinity for α3β4 nAChRs (Ki = 32 nM) and effectively inhibits nicotine-induced currents in electrophysiological assays. Functionally, SR 16584 reduces nicotine-induced dopamine release in the nucleus accumbens and demonstrates efficacy in preclinical models of nicotine dependence by reducing self-administration and withdrawal symptoms. These findings suggest its potential as a therapeutic agent for nicotine addiction and other disorders involving α3β4 nAChRs.
MedKoo Cat#: 128010
Name: SR-16584
CAS#: 1150153-86-8
Chemical Formula: C17H22N2O
Exact Mass: 270.1732
Molecular Weight: 270.38
Elemental Analysis: C, 75.52; H, 8.20; N, 10.36; O, 5.92
The following data is based on the product molecular weight 270.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
