Synonym
OA 6129C; OA-6129C; OA6129C; Antibiotic OA 6129C; Antibiotic OA-6129C; Antibiotic OA6129C;
IUPAC/Chemical Name
3-((2-(3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanamido)ethyl)thio)-7-oxo-6-(1-(sulfooxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
InChi Key
GRWWKENHBQJAML-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H31N3O11S2/c1-10(34-36(31,32)33)14-11-8-12(15(19(29)30)23(11)18(14)28)35-7-6-21-13(25)4-5-22-17(27)16(26)20(2,3)9-24/h10-11,14,16,24,26H,4-9H2,1-3H3,(H,21,25)(H,22,27)(H,29,30)(H,31,32,33)
SMILES Code
CC(C1C2CC(SCCNC(CCNC(C(C(C)(CO)C)O)=O)=O)=C(C(O)=O)N2C1=O)OS(=O)(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
553.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kojima I, Fukagawa Y, Okabe M, Ishikura T, Shibamoto N. Mutagenesis of OA-6129 carbapenem-producing blocked mutants and the biosynthesis of carbapenems. J Antibiot (Tokyo). 1988 Jul;41(7):899-907. doi: 10.7164/antibiotics.41.899. PMID: 3417564.
2: Kubo K, Ishikura T, Fukagawa Y. Microbial phosphorylation of the OA-6129 group of carbapenem compounds. J Antibiot (Tokyo). 1985 Mar;38(3):333-9. doi: 10.7164/antibiotics.38.333. PMID: 3839225.
3: Kubo K, Ishikura T, Fukagawa Y. Studies on the biosynthesis of carbapenem antibiotics. II. Isolation and functions of a specific acylase involved in the depantothenylation of the OA-6129 compounds. J Antibiot (Tokyo). 1984 Nov;37(11):1394-402. doi: 10.7164/antibiotics.37.1394. PMID: 6511667.
4: Fukagawa Y, Okabe M, Azuma S, Kojima I, Ishikura T, Kubo K. Studies on the biosynthesis of carbapenem antibiotics. I. Biosynthetic significance of the OA-6129 group of carbapenem compounds as the direct precursors for PS-5, epithienamycins A and C and MM 17880. J Antibiot (Tokyo). 1984 Nov;37(11):1388-93. doi: 10.7164/antibiotics.37.1388. PMID: 6511666.
5: Yoshioka T, Kojima I, Isshiki K, Watanabe A, Shimauchi Y, Okabe M, Fukagawa Y, Ishikura T. Structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics produced by Streptomyces sp. OA-6129. J Antibiot (Tokyo). 1983 Nov;36(11):1473-82. doi: 10.7164/antibiotics.36.1473. PMID: 6654757.
6: Okabe M, Azuma S, Kojima I, Kouno K, Okamoto R, Fukagawa Y, Ishikura T. Studies on the OA-6129 group of antibiotics, new carbapenem compounds. I. Taxonomy, isolation and physical properties. J Antibiot (Tokyo). 1982 Oct;35(10):1255-63. doi: 10.7164/antibiotics.35.1255. PMID: 7174513.
