MedKoo Cat#: 145541 | Name: Tasuldine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tasuldine (Ts) is an orally active bronchosecretolytic agent shown to be clinically effective in human studies. Tasuldine decreases the sialomucin content of the mucus and, in animal studies, this modulation of the glycopeptide correlates with decreased mucus viscosity.

Chemical Structure

Tasuldine
Tasuldine
CAS#88579-39-9

Theoretical Analysis

MedKoo Cat#: 145541

Name: Tasuldine

CAS#: 88579-39-9

Chemical Formula: C10H9N3S

Exact Mass: 203.0500

Molecular Weight: 203.26

Elemental Analysis: C, 59.09; H, 4.46; N, 20.67; S, 15.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Tasuldine;
IUPAC/Chemical Name
2-((pyridin-3-ylmethyl)thio)pyrimidine
InChi Key
HMCTXMOKMWELFJ-UHFFFAOYSA-N
InChi Code
1S/C10H9N3S/c1-3-9(7-11-4-1)8-14-10-12-5-2-6-13-10/h1-7H,8H2
SMILES Code
C(SC1=NC=CC=N1)C2=CC=CN=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 203.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: App EM, Tomkiewicz RP, Hahn HL, Engler H, Vergin H, King M. The effect of tasuldine, a bronchosecretolytic agent, on mucus rheology and clearability and the interaction with acetylcholine in ferrets. Pulm Pharmacol Ther. 1997 Oct- Dec;10(5-6):271-6. doi: 10.1006/pupt.1998.0103. PMID: 9778490. 2: Dorow P, Weiss T, Felix R, Köhler M. Influence of tasuldine and acetylcysteine on mucociliary clearance in patients with chronic airways obstruction. Arzneimittelforschung. 1986;36(1):131-3. PMID: 3954815. 3: Schickaneder H, Engler H, Szelenyi I. 2-[(3-Pyridinylmethyl)thio]pyrimidine derivatives: new bronchosecretolytic agents. J Med Chem. 1987 Mar;30(3):547-51. doi: 10.1021/jm00386a018. PMID: 3820227.