MedKoo Cat#: 127928 | Name: SW155246
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively.

Chemical Structure

SW155246
SW155246
CAS#420092-79-1

Theoretical Analysis

MedKoo Cat#: 127928

Name: SW155246

CAS#: 420092-79-1

Chemical Formula: C16H11ClN2O5S

Exact Mass: 378.0077

Molecular Weight: 378.78

Elemental Analysis: C, 50.74; H, 2.93; Cl, 9.36; N, 7.40; O, 21.12; S, 8.46

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
1g USD 4,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
SW155246; SW-155246; SW 155246
IUPAC/Chemical Name
4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide
InChi Key
JDYDEJYIVZNWQU-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H
SMILES Code
ClC1=CC=C(C=C1[N+]([O-])=O)S(NC2=CC=C(C3=C2C=CC=C3)O)(=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 378.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kilgore JA, Du X, Melito L, Wei S, Wang C, Chin HG, Posner B, Pradhan S, Ready JM, Williams NS. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem. 2013 Jul 5;288(27):19673-84. doi: 10.1074/jbc.M112.443895. Epub 2013 May 13. PMID: 23671287; PMCID: PMC3707673. 2: Medina-Franco JL, Méndez-Lucio O, Yoo J. Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking. Int J Mol Sci. 2014 Feb 21;15(2):3253-61. doi: 10.3390/ijms15023253. PMID: 24566147; PMCID: PMC3958909.