Synonym
4'-Bromo-resveratrol; 4' Bromo-resveratrol; 4'-Bromo resveratrol; 4′‐BR
IUPAC/Chemical Name
(E)-5-(4-bromostyryl)benzene-1,3-diol
InChi Key
NCJVLKFAQIWASE-OWOJBTEDSA-N
InChi Code
InChI=1S/C14H11BrO2/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,16-17H/b2-1+
SMILES Code
OC1=CC(O)=CC(/C=C/C2=CC=C(C=C2)Br)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
291.14
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tai YS, Ma YS, Chen CL, Tsai HY, Tsai CC, Wu MC, Chen CY, Lin MW. Resveratrol
Analog 4-Bromo-Resveratrol Inhibits Gastric Cancer Stemness through the
SIRT3-c-Jun N-Terminal Kinase Signaling Pathway. Curr Issues Mol Biol. 2021 Dec
22;44(1):63-72. doi: 10.3390/cimb44010005. PMID: 35723384; PMCID: PMC8929134.
2: George J, Nihal M, Singh CK, Ahmad N. 4'-Bromo-resveratrol, a dual Sirtuin-1
and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial
metabolic reprogramming. Mol Carcinog. 2019 Oct;58(10):1876-1885. doi:
10.1002/mc.23080. Epub 2019 Jul 10. PMID: 31292999; PMCID: PMC6721992.
3: Nguyen GT, Gertz M, Steegborn C. Crystal structures of Sirt3 complexes with
4'-bromo-resveratrol reveal binding sites and inhibition mechanism. Chem Biol.
2013 Nov 21;20(11):1375-85. doi: 10.1016/j.chembiol.2013.09.019. Epub 2013 Nov
7. PMID: 24211137.
4: Chhabra G, Singh CK, Guzmán-Pérez G, Ndiaye MA, Iczkowski KA, Ahmad N.
Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in
BrafV600E/PtenNULL Mice. J Invest Dermatol. 2022
Apr;142(4):1145-1157.e7. doi: 10.1016/j.jid.2021.08.434. Epub 2021 Sep 29. PMID:
34597611; PMCID: PMC9199498.
