RO-02-70608 | CAS#1160849-72-8 | R411 metabolite

MedKoo Cat#: 145536 | Name: RO-02-70608

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RO-02-70608 is a R411 metabolite. After single ascending oral doses of R411, area under the concentration-time curve from 0 to infinity of active metabolite RO0270608 increased proportionally from 150 to 1200 mg (P > .05).

Chemical Structure

RO-02-70608

CAS#1160849-72-8

Theoretical Analysis

MedKoo Cat#: 145536

Name: RO-02-70608

CAS#: 1160849-72-8

Chemical Formula: C23H18Cl3N3O4

Exact Mass: 505.0400

Molecular Weight: 506.76

Elemental Analysis: C, 54.51; H, 3.58; Cl, 20.99; N, 8.29; O, 12.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RO-02-70608; RO0270608; RO 02-70608;

IUPAC/Chemical Name

(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(3,5-dichloroisonicotinamido)phenyl)propanoic acid

InChi Key

WCGJWHNYKVSSFL-SFHVURJKSA-N

InChi Code

1S/C23H18Cl3N3O4/c1-12-3-2-4-15(24)19(12)21(30)29-18(23(32)33)9-13-5-7-14(8-6-13)28-22(31)20-16(25)10-27-11-17(20)26/h2-8,10-11,18H,9H2,1H3,(H,28,31)(H,29,30)(H,32,33)/t18-/m0/s1

SMILES Code

CC1=C(C(=O)N[C@@H](CC2=CC=C(NC(=O)C3=C(Cl)C=NC=C3Cl)C=C2)C(O)=O)C(Cl)=CC=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 506.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hijazi Y, Welker H, Dorr AE, Tang JP, Blain R, Renzetti LM, Abbas R. Pharmacokinetics, safety, and tolerability of R411, a dual alpha4beta1-alpha4beta7 integrin antagonist after oral administration at single and multiple once-daily ascending doses in healthy volunteers. J Clin Pharmacol. 2004 Dec;44(12):1368-78. doi: 10.1177/0091270004270147. PMID: 15545307.