FMAU | 2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil | CAS#69256-17-3 | Nucleosides

MedKoo Cat#: 122480 | Name: FMAU

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil is the impurity of antiviral drug Clevudine (C574150), which is used for the treatment of Hepatitis B.

Chemical Structure

FMAU

CAS#69256-17-3

Theoretical Analysis

MedKoo Cat#: 122480

Name: FMAU

CAS#: 69256-17-3

Chemical Formula: C10H13FN2O5

Exact Mass: 260.0808

Molecular Weight: 260.22

Elemental Analysis: C, 46.16; H, 5.04; F, 7.30; N, 10.77; O, 30.74

Price and Availability

Size	Price	Availability
100mg	USD 350.00	2 Weeks
250mg	USD 650.00	2 Weeks
500mg	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

FMAU; Clevudine; 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-methyluracil; D-FMAU; 2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil

IUPAC/Chemical Name

1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

InChi Key

GBBJCSTXCAQSSJ-JVZYCSMKSA-N

InChi Code

InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m1/s1

SMILES Code

O=C(N1)N([C@H]2[C@@H](F)[C@@H]([C@@H](CO)O2)O)C=C(C)C1=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 260.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jadvar H, Yap LP, Park R, Li Z, Chen K, Hughes L, Kouhi A, Conti P. [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations. Mol Imaging. 2012 Sep- Oct;11(5):426-32. PMID: 22954187; PMCID: PMC3443080. 2: Jadvar H, Park R, Yap LP, Chen K, Hughes L, Conti P. Effect of Androgen on Normal Biodistribution of [¹⁸F]-2'-Fluoro-5-methyl-1-beta-D- arabinofuranosyluracil (18F-FMAU) in Athymic Non-tumor-bearing Male Mice. Anticancer Res. 2017 Feb;37(2):475-479. doi: 10.21873/anticanres.11339. PMID: 28179292; PMCID: PMC5404414.