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MedKoo Cat#: 575434 | Name: FG-020326

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FG-020326 is a multidrug resistance modulator.

Chemical Structure

FG-020326
FG-020326
CAS#754191-70-3

Theoretical Analysis

MedKoo Cat#: 575434

Name: FG-020326

CAS#: 754191-70-3

Chemical Formula: C33H38N4O2

Exact Mass: 522.2995

Molecular Weight: 522.69

Elemental Analysis: C, 75.83; H, 7.33; N, 10.72; O, 6.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FG-020326; FG020326; FG 020326
IUPAC/Chemical Name
2-Propenoic acid, 3-(4-(4,5-bis(4-(methyl(1-methylethyl)amino)phenyl)-1H-imidazol-2-yl)phenyl)-, methyl ester, (2E)-
InChi Key
GJPYGCXUYYSCAJ-UFFVCSGVSA-N
InChi Code
InChI=1S/C33H38N4O2/c1-22(2)36(5)28-17-13-25(14-18-28)31-32(26-15-19-29(20-16-26)37(6)23(3)4)35-33(34-31)27-11-8-24(9-12-27)10-21-30(38)39-7/h8-23H,1-7H3,(H,34,35)/b21-10+
SMILES Code
COC(=O)\C=C\c1ccc(cc1)c2nc(c3ccc(cc3)N(C)C(C)C)c([nH]2)c4ccc(cc4)N(C)C(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 522.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Wang XW, Wang XK, Zhang X, Liang YJ, Shi Z, Chen LM, Fu LW. FG020326 sensitized multidrug resistant cancer cells to docetaxel-mediated apoptosis via enhancement of caspases activation. Molecules. 2012 May 9;17(5):5442-58. doi: 10.3390/molecules17055442. PMID: 22572929; PMCID: PMC6268253. 2. Deng WJ, Yang XQ, Liang YJ, Chen LM, Yan YY, Shuai XT, Fu LW. FG020326-loaded nanoparticle with PEG and PDLLA improved pharmacodynamics of reversing multidrug resistance in vitro and in vivo. Acta Pharmacol Sin. 2007 Jun;28(6):913-20. doi: 10.1111/j.1745-7254.2007.00565.x. PMID: 17506952. 3. Yang X, Deng W, Fu L, Blanco E, Gao J, Quan D, Shuai X. Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326. J Biomed Mater Res A. 2008 Jul;86(1):48-60. doi: 10.1002/jbm.a.31537. PMID: 17941015.