GSK3335103 is a Highly Potent and Orally Bioavailable Nonpeptidic αvβ6 Integrin Inhibitor. GSK3335103 was found to have highly desirable oral pharmacokinetic profiles in rat, dog, and minipig, with low to moderate clearance (26%, 7%, and 18% liver blood flow, respectively), moderate volumes of distribution (3.6, 1.4, and 0.9 L/kg, respectively), high to complete oral bioavailabilities, high αvβ6 integrin potency of pIC50 of 8.0, and high solubility in physiological media (>2 mg/mL).
MedKoo Cat#: 127829
Name: GSK3335103
CAS#: 1893340-21-0 (free base)
Chemical Formula: C27H36FN3O4
Exact Mass: 485.2690
Molecular Weight: 485.60
Elemental Analysis: C, 66.78; H, 7.47; F, 3.91; N, 8.65; O, 13.18
The following data is based on the product molecular weight 485.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
