TYRA-300 is an Oral Selective FGFR3 Inhibitor (IC50 = 11 nM) for the Treatment of Urothelial Cancers and Achondroplasia. TYRA-300 was conceived using a structure-based approach as a potent FGFR3-selective inhibitor to avoid the toxicities associated with inhibition of FGFR1, FGFR2, and FGFR4, and to be agnostic for the FGFR3 gatekeeper mutations.
MedKoo Cat#: 127786
Name: TYRA-300
CAS#: 2800223-30-5
Chemical Formula: C25H24Cl2N6O3S
Exact Mass: 558.1008
Molecular Weight: 559.47
Elemental Analysis: C, 53.67; H, 4.32; Cl, 12.67; N, 15.02; O, 8.58; S, 5.73
The following data is based on the product molecular weight 559.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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