ACP6-12 is an ClpP activator and antibiotics. ACP6-12 exhibited over a 10-fold increase in activity over the parent ACP1-06 compound, and a cocrystal X-ray structure with ClpP confirmed its predicted binding conformation. This allowed for a comparative analysis of how different ligand classes bind to the hydrophobic binding site.
MedKoo Cat#: 127753
Name: ACP6-12
CAS#: N/A
Chemical Formula: C25H21F9N3O2PS
Exact Mass: 629.0948
Molecular Weight: 629.48
Elemental Analysis: C, 47.70; H, 3.36; F, 27.16; N, 6.68; O, 5.08; P, 4.92; S, 5.09
The following data is based on the product molecular weight 629.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |