MP-11 is a potent MLKL PROTAC degrader. MP-11 showed lower toxicity than the original MLKL ligand, exhibiting nanomolar scale antinecroptotic activity on human cell lines. Xenograft model studies showed that MP-11 effectively degraded MLKL in vivo. Importantly, our study demonstrates that the covalent binding strategy is an effective approach for designing MLKL-targeting PROTACs, serving as a model for developing PROTACs to treat future necroptosis-related human diseases.
MedKoo Cat#: 127713
Name: MP11
CAS#: N/A
Chemical Formula: C36H35N9O9S
Exact Mass: 769.2278
Molecular Weight: 769.79
Elemental Analysis: C, 56.17; H, 4.58; N, 16.38; O, 18.71; S, 4.16
The following data is based on the product molecular weight 769.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
