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MedKoo Cat#: 563802 | Name: GPU-028

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GPU-028 is a potent free fatty acid receptor 4 (FFA4) agonist. GPU-028 functions in improvement of insulin secretion and insulin resistance.

Chemical Structure

GPU-028
GPU-028
CAS#1374516-07-0

Theoretical Analysis

MedKoo Cat#: 563802

Name: GPU-028

CAS#: 1374516-07-0

Chemical Formula: C23H19D2FO3

Exact Mass: 366.1600

Molecular Weight: 366.43

Elemental Analysis: C, 75.39; H, 6.33; F, 5.18; O, 13.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GPU-028; GPU-028; GPU-028; 2,2-d2-TUG-891; 2,2d2TUG891; 2,2 d2 TUG 891
IUPAC/Chemical Name
3-(4-((4-Fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic-2,2-d2 acid
InChi Key
LPGBXHWIQNZEJB-KLTYLHELSA-N
InChi Code
InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)/i13D2
SMILES Code
[2H]C(CC1=CC=C(OCC2=CC(F)=CC=C2C3=CC=C(C)C=C3)C=C1)([2H])C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
GPU-028 revealed a longer half-life (T1/2 = 1.66 h), lower clearance (CL = 0.97 L/h/kg), and higher maximum plasma concentration, resulting in a 4-fold higher exposure than TUG-891.

Preparing Stock Solutions

The following data is based on the product molecular weight 366.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Z, Xu X, Li G, Fu X, Liu Y, Feng Y, Wang M, Ouyang Y, Han J. Improving metabolic stability with deuterium: The discovery of GPU-028, a potent free fatty acid receptor 4 agonists. Bioorg Med Chem. 2017 Dec 15;25(24):6647-6652. doi: 10.1016/j.bmc.2017.10.040. Epub 2017 Oct 31. PubMed PMID: 29100735.