IHMT-PI3K-315 | PI3Kγ | PI3Kδ | AKT S473

MedKoo Cat#: 127673 | Name: IHMT-PI3K-315

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IHMT-PI3K-315 is a potent and selective dual inhibitor of PI3Kγ and PI3Kδ. IHMT-PI3K-315 displays an IC50 value of 4.0 and 9.1 nM against PI3Kγ and PI3Kδ respectively in biochemical assays. Meanwhile, it potently inhibits PI3Kγ and PI3Kδ-mediated phosphorylation of AKT S473 with EC50 values of 0.028 and 0.013 μM in cellular assays. In addition, IHMT-PI3K-315 exhibits a favorable selectivity profile in protein kinases at 1 μM. In bone marrow-derived macrophages (BMDM).

Chemical Structure

IHMT-PI3K-315

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127673

Name: IHMT-PI3K-315

CAS#: N/A

Chemical Formula: C22H20F2N6O4

Exact Mass: 470.1514

Molecular Weight: 470.44

Elemental Analysis: C, 56.17; H, 4.29; F, 8.08; N, 17.86; O, 13.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IHMT-PI3K-315; IHMT-PI3K 315; IHMT PI3K-315

IUPAC/Chemical Name

1-(5-(5-(difluoromethoxy)-6-methoxypyridin-3-yl)pyrazolo[1,5-a]pyridin-2-yl)-3-(2-(pyridin-3-yloxy)ethyl)urea

InChi Key

RMENQCHAGAXAKH-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H20F2N6O4/c1-32-20-18(34-21(23)24)10-15(12-27-20)14-4-7-30-16(9-14)11-19(29-30)28-22(31)26-6-8-33-17-3-2-5-25-13-17/h2-5,7,9-13,21H,6,8H2,1H3,(H2,26,28,29,31)

SMILES Code

O=C(NC1=NN2C(C=C(C3=CC(OC(F)F)=C(OC)N=C3)C=C2)=C1)NCCOC4=CN=CC=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 470.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Wang C, Zou F, Qi Z, Liu Q, Shen L, Yuan X, Deng M, Wang A, Wang B, Wang L, Liang X, Liu Q, Liu J. Discovery of Pyrazolo[1,5-a]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors. J Med Chem. 2024 Aug 20. doi: 10.1021/acs.jmedchem.4c00817. Epub ahead of print. PMID: 39163191.