MS182 is an p53Y220C AceTAC. MS182 effectively acetylated p53Y220C at lysine 382 in a time- and concentration dependent manner via inducing the ternary complex formation between p300/CBP acetyltransferase and p53Y220C. 11 was more effective than the parent p53Y220C stabilizer in suppressing the proliferation and clonogenicity in cancer cells harboring the p53Y200C mutation and was bioavailable in mice. Overall, 11 is a potentially valuable chemical tool to investigate the role of p53Y220C acetylation in cancer.
MedKoo Cat#: 127610
Name: MS182
CAS#: N/A
Chemical Formula: C57H68FN7O7S
Exact Mass: 1013.4885
Molecular Weight: 1014.27
Elemental Analysis: C, 67.50; H, 6.76; F, 1.87; N, 9.67; O, 11.04; S, 3.16
The following data is based on the product molecular weight 1,014.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
