Synonym
360A (iodide); 360A iodide; 360A
IUPAC/Chemical Name
3,3'-((pyridine-2,6-dicarbonyl)bis(azanediyl))bis(1-methylquinolin-1-ium) iodide
InChi Key
CYDYPTJPHHNFEL-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H21N5O2.2HI/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21;;/h3-17H,1-2H3;2*1H
SMILES Code
O=C(C1=CC=CC(C(NC2=CC3=C([N+](C)=C2)C=CC=C3)=O)=N1)NC4=CC5=C([N+](C)=C4)C=CC=C5.[I-].[I-]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
703.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hwang IP, Mailliet P, Hossard V, Riou JF, Bugaut A, Roger L. Investigating
the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability
by Single Telomere Length Analysis (STELA). Molecules. 2019 Feb 6;24(3):577.
doi: 10.3390/molecules24030577. PMID: 30736276; PMCID: PMC6384687.
2: Pennarun G, Granotier C, Hoffschir F, Mandine E, Biard D, Gauthier LR,
Boussin FD. Role of ATM in the telomere response to the G-quadruplex ligand
360A. Nucleic Acids Res. 2008 Mar;36(5):1741-54. doi: 10.1093/nar/gkn026. Epub
2008 Feb 7. PMID: 18263609; PMCID: PMC2275132.
3: Stoor K, Karvonen E, Liinamaa J, Saarela V. Evaluating refraction and visual
acuity with the Nidek autorefractometer AR-360A in a randomized population-based
screening study. Acta Ophthalmol. 2018 Jun;96(4):384-389. doi:
10.1111/aos.13636. Epub 2017 Nov 30. PMID: 29193822.
4: Gauthier LR, Granotier C, Hoffschir F, Etienne O, Ayouaz A, Desmaze C,
Mailliet P, Biard DS, Boussin FD. Rad51 and DNA-PKcs are involved in the
generation of specific telomere aberrations induced by the quadruplex ligand
360A that impair mitotic cell progression and lead to cell death. Cell Mol Life
Sci. 2012 Feb;69(4):629-40. doi: 10.1007/s00018-011-0767-6. Epub 2011 Jul 20.
PMID: 21773671; PMCID: PMC3265728.
5: Ghoraba HH, Ellakwa AF, Ghali AA, Abdel Fattah HM. Long-term results of 360A°
scleral buckling and vitrectomy with silicone oil tamponade for management of
gunshot-perforating ocular injury. Eye (Lond). 2012 Oct;26(10):1318-23. doi:
10.1038/eye.2012.150. Epub 2012 Aug 3. PMID: 22863820; PMCID: PMC3470064.
