LOR17 | KOR agonist | Kappa-Opioid Receptor

MedKoo Cat#: 127586 | Name: LOR17

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LOR17 is an KOR agonist (Kappa-Opioid Receptor agonist).

Chemical Structure

LOR17

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127586

Name: LOR17

CAS#: N/A

Chemical Formula: C25H27N5O4

Exact Mass: 461.2063

Molecular Weight: 461.52

Elemental Analysis: C, 65.06; H, 5.90; N, 15.17; O, 13.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LOR17; LOR 17; LOR-17

IUPAC/Chemical Name

(6S,9R)-9-((1H-indol-3-yl)methyl)-6-benzyl-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetraone

InChi Key

NYJFLKFMMFVJNM-LEWJYISDSA-N

InChi Code

InChI=1S/C25H27N5O4/c31-22-10-11-26-23(32)15-28-24(33)20(12-16-6-2-1-3-7-16)30-25(34)21(29-22)13-17-14-27-19-9-5-4-8-18(17)19/h1-9,14,20-21,27H,10-13,15H2,(H,26,32)(H,28,33)(H,29,31)(H,30,34)/t20-,21+/m0/s1

SMILES Code

O=C(N[C@@H](CC1=CC=CC=C1)C2=O)[C@H](NC(CCNC(CN2)=O)=O)CC3=CNC4=C3C=CC=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 461.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Bedini A, Di Cesare Mannelli L, Micheli L, Baiula M, Vaca G, De Marco R, Gentilucci L, Ghelardini C, Spampinato S. Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist. Front Pharmacol. 2020 Mar 5;11:188. doi: 10.3389/fphar.2020.00188. PMID: 32210803; PMCID: PMC7066533.