SDUY038 is an SHP2 allosteric inhibitor. SDUY038 demonstrated potent binding affinity (KD = 0.29 μM), enzymatic activity (IC50 = 1.2 μM) and similar binding interactions to SHP099. At the cellular level, SDUY038 exhibited pan-antitumor activity (IC50 = 7−24 μM) by suppressing pERK expression. Furthermore, SDUY038 significantly inhibited tumor growth in both xenograft and organoid models. Additionally, SDUY038 displayed acceptable bioavailability (F = 14%) and half-life time (t1/2 = 3.95 h).
MedKoo Cat#: 127577
Name: SDUY038
CAS#: N/A
Chemical Formula: C17H18Cl2N2O2S
Exact Mass: 384.0466
Molecular Weight: 385.30
Elemental Analysis: C, 52.99; H, 4.71; Cl, 18.40; N, 7.27; O, 8.30; S, 8.32
The following data is based on the product molecular weight 385.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
