Articainic acid | CAS#114176-52-2 | Anesthetic

MedKoo Cat#: 150174 | Name: Articainic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Articainic acid is a metabolite of articaine, a local anesthetic used in dentistry and other procedures. Articaine is an amide anesthetic that contains a thiophene ring, which makes it more lipid soluble and able to diffuse across nerve membranes.

Chemical Structure

Articainic acid

CAS#114176-52-2

Theoretical Analysis

MedKoo Cat#: 150174

Name: Articainic acid

CAS#: 114176-52-2

Chemical Formula: C12H18N2O3S

Exact Mass: 270.1040

Molecular Weight: 270.35

Elemental Analysis: C, 53.31; H, 6.71; N, 10.36; O, 17.75; S, 11.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

articaine acid; Articainic acid;

IUPAC/Chemical Name

4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylic acid

InChi Key

LUPKINKNYDFRIB-UHFFFAOYSA-N

InChi Code

1S/C12H18N2O3S/c1-4-5-13-8(3)11(15)14-9-7(2)6-18-10(9)12(16)17/h6,8,13H,4-5H2,1-3H3,(H,14,15)(H,16,17)

SMILES Code

O=C(C1=C(NC(C(NCCC)C)=O)C(C)=CS1)O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 270.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Venkatachalam D, Chambers JP, Kongara K, Singh P. Pharmacokinetics of articaine hydrochloride and its metabolite articainic acid after subcutaneous administration in red deer (Cervus elaphus). N Z Vet J. 2018 Jan;66(1):16-20. doi: 10.1080/00480169.2017.1391141. Epub 2017 Oct 23. PMID: 29020878. 2: Vree TB, Van Oss GE, Gielen MJ, Booij LH. Epidural metabolism of articaine to its metabolite articainic acid in five patients after epidural administration of 600 mg articaine. J Pharm Pharmacol. 1997 Feb;49(2):158-63. doi: 10.1111/j.2042-7158.1997.tb06772.x. PMID: 9055188. 3: van Oss GE, Vree TB, Baars AM, Termond EF, Booij LH. Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration. Eur J Anaesthesiol. 1989 Jan;6(1):49-56. PMID: 2714265. 4: Van Oss GE, Vree TB, Baars AM, Termond EF, Booij LH. Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration. Pharm Weekbl Sci. 1988 Dec 9;10(6):284-6. doi: 10.1007/BF02219670. PMID: 3211703.