MedKoo Cat#: 145398 | Name: Fourphit

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fourphit is a phencyclidine derivative containing an isothiocyanate substitution at the 4-position of the piperidine ring. FOURPHIT inhibits the binding of [3H]methylphenidate to sites on the dopamine transport complex. FOURPHIT may be useful as a relatively selective affinity label for the site on the dopamine transport complex recognized by methylphenidate and other psychomotor stimulants.

Chemical Structure

Fourphit
Fourphit
CAS#104639-01-2

Theoretical Analysis

MedKoo Cat#: 145398

Name: Fourphit

CAS#: 104639-01-2

Chemical Formula: C18H24N2S

Exact Mass: 300.1660

Molecular Weight: 300.46

Elemental Analysis: C, 71.95; H, 8.05; N, 9.32; S, 10.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fourphit;
IUPAC/Chemical Name
4-isothiocyanato-1-(1-phenylcyclohexyl)piperidine
InChi Key
QAHYIAVTWZVTMY-UHFFFAOYSA-N
InChi Code
1S/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2
SMILES Code
S=C=NC1CCN(CC1)C2(CCCCC2)C3=CC=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schweri MM, Thurkauf A, Mattson MV, Rice KC. Fourphit: a selective probe for the methylphenidate binding site on the dopamine transporter. J Pharmacol Exp Ther. 1992 Jun;261(3):936-42. PMID: 1602399. 2: Schweri MM, de Costa BR, Rice KC. Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats. Pharmacol Biochem Behav. 1998 Jul;60(3):615-23. doi: 10.1016/s0091-3057(98)00040-9. PMID: 9678644. 3: Bolger GT, Rafferty MF, Weissman BA, Rice KC, Skolnick P. Acylating phencyclidines irreversibly enhance brain calcium antagonist binding. Pharmacol Biochem Behav. 1986 Jul;25(1):51-7. doi: 10.1016/0091-3057(86)90229-7. PMID: 2944131. 4: Rice KC, Bolger GT. Interactions between phencyclidine and nifedipine at 45Ca2(+)-uptake sites on mouse brain neurons. Biochem Pharmacol. 1990 Jun 1;39(11):1825-7. doi: 10.1016/0006-2952(90)90134-7. PMID: 2160822.