MedKoo Cat#: 150154 | Name: Dexamethasone Pivalate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexamethasone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, kidney problems, skin conditions, and flare-ups of multiple sclerosis.

Chemical Structure

Dexamethasone Pivalate
Dexamethasone Pivalate
CAS#1926-94-9

Theoretical Analysis

MedKoo Cat#: 150154

Name: Dexamethasone Pivalate

CAS#: 1926-94-9

Chemical Formula: C27H37FO6

Exact Mass: 476.2570

Molecular Weight: 476.59

Elemental Analysis: C, 68.05; H, 7.83; F, 3.99; O, 20.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dexamethasone pivalate; Dexamethasone 21-pivalate; Dexamethasone trimethyl acetate;
IUPAC/Chemical Name
[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate
InChi Key
XMQRFWOHEPJZPS-JHUFMRCFSA-N
InChi Code
1S/C27H37FO6/c1-15-11-19-18-8-7-16-12-17(29)9-10-24(16,5)26(18,28)20(30)13-25(19,6)27(15,33)21(31)14-34-22(32)23(2,3)4/h9-10,12,15,18-20,30,33H,7-8,11,13-14H2,1-6H3/t15-,18+,19+,20+,24+,25+,26+,27+/m1/s1
SMILES Code
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(COC(C(C)(C)C)=O)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 476.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kalliomäki JL. Dexamethasone pivalate, an anti-inflammatory corticosteroid with prolonged effect in parenteral use: some clinical and endocrinological observations. Curr Ther Res Clin Exp. 1967 Jul;9(7):327-37. PMID: 4963160. 2: Chattopadhyay SP, Arora PN, Anand S, Sharma SD. Betamethasone dipropionate (0.05%) plus salicylic acid (3%) ointment versus dexamethasone trimethyl acetate (1%) and salicylic acid 4% ointments in chronic dermatoses. Indian J Dermatol. 1987 Apr;32(2):41-4. PMID: 3453353. 3: Simon F, Laczay P, Móra Z, Lehel J. Target animal safety test of a dexamethasone-prednisolone combination in horses. Dtsch Tierarztl Wochenschr. 1990 Sep;97(9):339-40,342. PMID: 2242726. 4: MacDiarmid SC. Betamethasone alcohol suspensions for the induction of parturition in dairy cows: a comparison with dexamethasone trimethyl acetate. N Z Vet J. 1979 May;27(5):86-9. doi: 10.1080/00480169.1979.34607. PMID: 292913.