Dexisometheptene is an antimigraine drug candidate. The active ingredient in TNX-201 is dexisometheptene mucate, the (R) isomer of isometheptene mucate. TNX-201 significantly increases the pain threshold of acute pain response, and potently and selectively binds to receptors in the central nervous system known as imidazoline type-1 (I1) receptors, where it acts as a receptor agonist.
MedKoo Cat#: 327005
Name: Dexisometheptene
CAS#: 1620401-56-0 (free base)
Chemical Formula: C9H19N
Exact Mass: 141.1517
Molecular Weight: 141.26
Elemental Analysis: C, 76.53; H, 13.56; N, 9.92
The following data is based on the product molecular weight 141.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
