EA-2192 | CAS#73207-98-4 | VX metabolite

MedKoo Cat#: 145381 | Name: EA-2192

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EA-2192 is a VX metabolite. EA-2192 is the most toxic and persistent degradation product of the nerve agent VX. EA-2192 is also known as methylphosphonothioic acid.

Chemical Structure

EA-2192

CAS#73207-98-4

Theoretical Analysis

MedKoo Cat#: 145381

Name: EA-2192

CAS#: 73207-98-4

Chemical Formula: C9H22NO2PS

Exact Mass: 239.1109

Molecular Weight: 239.31

Elemental Analysis: C, 45.17; H, 9.27; N, 5.85; O, 13.37; P, 12.94; S, 13.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

EA-2192; EA2192; EA 2192;

IUPAC/Chemical Name

S-(2-(diisopropylamino)ethyl) O-hydrogen methylphosphonothioate

InChi Key

UOXJNGFFPMOZDM-UHFFFAOYSA-N

InChi Code

1S/C9H22NO2PS/c1-8(2)10(9(3)4)6-7-14-13(5,11)12/h8-9H,6-7H2,1-5H3,(H,11,12)

SMILES Code

CC(C)N(CCSP(C)(O)=O)C(C)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 239.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schmitt C, Koller M, Köhler A, Worek F. Determination of tissue distribution of VX and its metabolites EMPA and EA-2192 in various rat tissues by LC-ESI- MS/MS after phosphotriesterase treatment. Toxicol Lett. 2024 Jul;398:13-18. doi: 10.1016/j.toxlet.2024.06.003. Epub 2024 Jun 8. PMID: 38857853. 2: Ghanem E, Li Y, Xu C, Raushel FM. Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX. Biochemistry. 2007 Aug 7;46(31):9032-40. doi: 10.1021/bi700561k. Epub 2007 Jul 14. PMID: 17630782. 3: Dhar BB, Edwards DR, Brown RS. A study of the kinetics of La3+-promoted methanolysis of S-aryl methylphosphonothioates: possible methodology for decontamination of EA 2192, the toxic byproduct of VX hydrolysis. Inorg Chem. 2011 Apr 4;50(7):3071-7. doi: 10.1021/ic200007v. Epub 2011 Mar 9. PMID: 21388185. 4: Munro NB, Talmage SS, Griffin GD, Waters LC, Watson AP, King JF, Hauschild V. The sources, fate, and toxicity of chemical warfare agent degradation products. Environ Health Perspect. 1999 Dec;107(12):933-74. doi: 10.1289/ehp.99107933. PMID: 10585900; PMCID: PMC1566810. 5: Reiter G, Mikler J, Hill I, Weatherby K, Thiermann H, Worek F. Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 15;879(26):2704-13. doi: 10.1016/j.jchromb.2011.07.031. Epub 2011 Jul 30. PMID: 21862421. 6: Subramaniam R, Åstot C, Juhlin L, Nilsson C, Östin A. Determination of S-2-(N,N-diisopropylaminoethyl)- and S-2-(N,N-diethylaminoethyl) methylphosphonothiolate, nerve agent markers, in water samples using strong anion-exchange disk extraction, in vial trimethylsilylation, and gas chromatography-mass spectrometry analysis. J Chromatogr A. 2012 Mar 16;1229:86-94. doi: 10.1016/j.chroma.2012.01.068. Epub 2012 Jan 31. PMID: 22326187. 7: Clay WK, Buck AK, He Y, Hernández Sánchez DN, Ward NA, Lear JM, Nguyen KQ, Clark BH, Sapia RJ, Lalisse RF, Sriraman A, Cadieux CL, McElroy CA, Callam CS, Hadad CM. Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase. Chem Res Toxicol. 2024 Apr 15;37(4):643-657. doi: 10.1021/acs.chemrestox.4c00024. Epub 2024 Mar 31. PMID: 38556765. 8: Moon SY, Wagner GW, Mondloch JE, Peterson GW, DeCoste JB, Hupp JT, Farha OK. Effective, Facile, and Selective Hydrolysis of the Chemical Warfare Agent VX Using Zr6-Based Metal-Organic Frameworks. Inorg Chem. 2015 Nov 16;54(22):10829-33. doi: 10.1021/acs.inorgchem.5b01813. Epub 2015 Oct 27. PMID: 26505999. 9: Gon Ryu S, Wan Lee H. Effectiveness and reaction networks of H2O2 vapor with NH3 gas for decontamination of the toxic warfare nerve agent, VX on a solid surface. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2015;50(14):1417-27. doi: 10.1080/10934529.2015.1071155. Epub 2015 Sep 1. PMID: 26327407.