Thiocolchicine | CAS#2730-71-4 | microtublin inhibitor

MedKoo Cat#: 406478 | Name: Thiocolchicine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiocolchicine is a potent tubulin polymerization and microtubule assembly inhibitor, a axonal cytoskeleton modulator and apoptosis inducer. Structurally, thiocolchicine is a colchicine analog in which the C-10 methoxy is replaced with a thiomethyl moiety. Thiocolchicine was shown to bind with high affinity to the colchicine site on tubulin (Ka = 1.07 +/- 0.14 x 10(6) M-1). Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.

Chemical Structure

Thiocolchicine

CAS#2730-71-4

Theoretical Analysis

MedKoo Cat#: 406478

Name: Thiocolchicine

CAS#: 2730-71-4

Chemical Formula: C22H25NO5S

Exact Mass: 415.1453

Molecular Weight: 415.50

Elemental Analysis: C, 63.59; H, 6.06; N, 3.37; O, 19.25; S, 7.72

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 150.00
10mg	USD 250.00
25mg	USD 450.00

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Related CAS #

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Synonym

Thiocolchicine.

IUPAC/Chemical Name

N-(1,2,3-trimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

InChi Key

CMEGANPVAXDBPL-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

SMILES Code

CC(NC1CCC2=CC(OC)=C(OC)C(OC)=C2C3=CC=C(SC)C(C=C13)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 32151042; PMCID: PMC7179419. 7: Urbaniak A, Jousheghany F, Piña-Oviedo S, Yuan Y, Majcher-Uchańska U, Klejborowska G, Moorjani A, Monzavi-Karbassi B, Huczyński A, Chambers TC. Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study. J Biochem Mol Toxicol. 2020 Jun;34(6):e22487. doi: 10.1002/jbt.22487. Epub 2020 Mar 5. PMID: 32141170. 8: Klejborowska G, Urbaniak A, Maj E, Preto J, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A. Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents. Bioorg Chem. 2020 Apr;97:103664. doi: 10.1016/j.bioorg.2020.103664. Epub 2020 Feb 13. PMID: 32106039. 9: Bonandi E, Foschi F, Marucci C, Dapiaggi F, Sironi M, Pieraccini S, Christodoulou MS, de Asís Balaguer F, Díaz JF, Zidar N, Passarella D. 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