MedKoo Cat#: 150143 | Name: Dimethyl Isosorbide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethyl Isosorbide is a dimethyl ether of an anhydride of an isomer of sorbitol. It can be synthetic or plant-derived and is considered safe and non-irritating. DMI is used in products such as creams, lotions, sprays, sunless tanners, facial and eye-zone treatments, skin serums, anti-acne formulations, and make-up removers.

Chemical Structure

Dimethyl Isosorbide
CAS#5306-85-4

Theoretical Analysis

MedKoo Cat#: 150143

Name: Dimethyl Isosorbide

CAS#: 5306-85-4

Chemical Formula: C8H14O4

Exact Mass: 174.0890

Molecular Weight: 174.20

Elemental Analysis: C, 55.16; H, 8.10; O, 36.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Dimethyl isosorbide; Isosorbide dimethyl ether; 2,5-Dimethylisosorbide; DMI;
IUPAC/Chemical Name
(3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan
InChi Key
MEJYDZQQVZJMPP-ULAWRXDQSA-N
InChi Code
1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1
SMILES Code
CO[C@H]1CO[C@@]2([H])[C@]1([H])OC[C@H]2OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 174.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Aricò F, Aldoshin AS, Tundo P. One-Pot Preparation of Dimethyl Isosorbide from d-Sorbitol via Dimethyl Carbonate Chemistry. ChemSusChem. 2017 Jan 10;10(1):53-57. doi: 10.1002/cssc.201601382. Epub 2016 Dec 22. PMID: 27922205. 2: Su M, Huang X, Lei C, Jin J. Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent. Org Lett. 2022 Jan 14;24(1):354-358. doi: 10.1021/acs.orglett.1c04018. Epub 2021 Dec 28. PMID: 34962407. 3: Zia H, Ma JK, O'Donnell JP, Luzzi LA. Cosolvency of dimethyl isosorbide for steroid solubility. Pharm Res. 1991 Apr;8(4):502-4. doi: 10.1023/a:1015807413141. PMID: 1871047. 4: Squillante E, Needham T, Maniar A, Kislalioglu S, Zia H. Codiffusion of propylene glycol and dimethyl isosorbide in hairless mouse skin. Eur J Pharm Biopharm. 1998 Nov;46(3):265-71. doi: 10.1016/s0939-6411(98)00030-7. PMID: 9885297.