Synonym
Levistilide A; Levistilide-A
IUPAC/Chemical Name
(1Z,5S,5aS,8Z,10bS,10cS)-1,8-Dibutylidene-5,5a,6,7-tetrahydro-1H-5,10c-ethanonaphtho[1,2-c:7,8-c']difuran-3,10(8H,10bH)-dione
InChi Key
UBBRXVRQZJSDAK-ZJHGLIIDSA-N
InChi Code
InChI=1S/C24H28O4/c1-3-5-7-18-16-10-9-15-14-11-12-24(21(15)20(16)23(26)27-18)17(13-14)22(25)28-19(24)8-6-4-2/h7-8,13-15,21H,3-6,9-12H2,1-2H3/b18-7-,19-8-/t14-,15+,21-,24+/m1/s1
SMILES Code
O=C(O/C([C@@]1(CC2)[C@]34[H])=C\CCC)C1=C[C@]2([H])[C@]3([H])CCC5=C4C(O/C5=C\CCC)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
380.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lei XQ, Li G, Cheng L, Wang XL, Meng FY. Identification of Ligustici Rhizoma et Radix and its adulterants based on their chemical constituents by UHPLC-Q/TOF-MS combined with data mining. J Pharm Biomed Anal. 2018 May 30;154:123-137. doi: 10.1016/j.jpba.2018.02.053. Epub 2018 Feb 25. PubMed PMID: 29571130.
2: Zhao ZM, Liu HL, Sun X, Guo T, Shen L, Tao YY, Liu CH. Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway. Exp Biol Med (Maywood). 2017 May;242(9):974-985. doi: 10.1177/1535370217701005. Epub 2017 Mar 22. PubMed PMID: 28440736; PubMed Central PMCID: PMC5407594.
3: Ma W, Wang W, Peng Y, Bian Q, Wang N, Lee DY, Dai R. Ultra-high performance liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of five phthalides in rat plasma: Application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and herb-pair extract. J Sep Sci. 2016 Jun;39(11):2057-67. doi: 10.1002/jssc.201600023. Epub 2016 May 17. PubMed PMID: 27062714.
4: He WQ, Lv WS, Zhang Y, Qu Z, Wei RR, Zhang L, Liu CH, Zhou XX, Li WR, Huang XT, Wang Q. Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS. J Chromatogr Sci. 2015 Sep;53(8):1265-73. doi: 10.1093/chromsci/bmu224. Epub 2015 Feb 5. PubMed PMID: 25657289.
