Synonym
Co(III) Protoporphyrin IX chloride; Co(III) Protoporphyrin-IX chloride; Co (III) Protoporphyrin IX chloride;
InChi Key
WWNXKQFLDNSNDN-HXFTUNQESA-K
InChi Code
InChI=1S/C34H34N4O4.ClH.Co/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
SMILES Code
CC1=C(C(/C=C2C(CCC(O)=O)=C3C)=N/C1=C\C4=C(C(C)=C5N4[Co](N/2/C3=C\C(C(C)=C/6C=C)=NC6=C/5)Cl)C=C)CCC(O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
655.04
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1.) Dennis, Michael; Kolattukudy, P. E., A cobalt-porphyrin enzyme converts a fatty aldehyde to a hydrocarbon and carbon monoxide, Proceedings of the National Academy of Sciences of the United States of America (1992), 89(12), 5306-10. DOI:10.1073/pnas.89.12.5306.
2.) Botelho do Rego, A. M.; Ferraria, A. M.; Rei Vilar, M., Grafting of Cobaltic Protoporphyrin IX on Semiconductors toward Sensing Devices: Vibrational and Electronic High-Resolution Electron Energy Loss Spectroscopy and X-ray Photoelectron Spectroscopy Study, Journal of Physical Chemistry C (2013), 117(43), 22298-22306. DOI:10.1021/jp402032x.
3.) Onyiah, Joseph C.; Sheikh, Shehzad Z.; Maharshak, Nitsan; Steinbach, Erin C.; Russo, Steven M.; Kobayashi, Taku; Mackey, Lantz C.; Hansen, Jonathan J.; Moeser, Adam J.; Rawls, John F.; et al, Carbon Monoxide and Heme Oxygenase-1 Prevent Intestinal Inflammation in Mice by Promoting Bacterial Clearance, Gastroenterology (2013), 144(4), 789-798. .2012.12.025.
4.) Lakkisto, Paivi; Kyto, Ville; Forsten, Hanna; Siren, Juha-Matti; Segersvard, Heli; Voipio-Pulkki, Liisa-Maria; Laine, Mika; Pulkki, Kari; Tikkanen, Ilkka, Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1α, SDF-1α and VEGF-B, European Journal of Pharmacology (2010), 635(1-3), 156-164, DOI:10.1016/j.ejphar.2010.02.050
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