DEC-TA 870 | CAS#122570-36-9 | Ta-870 metabolite

MedKoo Cat#: 145363 | Name: DEC-TA 870

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DEC-TA 870 is a de-ethoxycarbonyl metabolite of TA-870. DEC-TA-870 causes weak relaxant effects on PGF2 alpha-induced contraction in rabbits. DEC-TA-870 exerts weak vasodilatory effects that are different from that of dopamine in vitro, and that TA-870 exerts its vasodilatory effect after its conversion to free dopamine in vivo.

Chemical Structure

DEC-TA 870

CAS#122570-36-9

Theoretical Analysis

MedKoo Cat#: 145363

Name: DEC-TA 870

CAS#: 122570-36-9

Chemical Formula: C15H22N2O4S

Exact Mass: 326.1300

Molecular Weight: 326.41

Elemental Analysis: C, 55.20; H, 6.79; N, 8.58; O, 19.61; S, 9.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DEC-TA 870; DEC-TA-870; DEC TA 870; DECTA870;

IUPAC/Chemical Name

(S)-2-acetamido-N-(3,4-dihydroxyphenethyl)-4-(methylthio)butanamide

InChi Key

QCDZESBHHYRZDC-LBPRGKRZSA-N

InChi Code

1S/C15H22N2O4S/c1-10(18)17-12(6-8-22-2)15(21)16-7-5-11-3-4-13(19)14(20)9-11/h3-4,9,12,19-20H,5-8H2,1-2H3,(H,16,21)(H,17,18)/t12-/m0/s1

SMILES Code

CSCC[C@H](NC(C)=O)C(=O)NCCC1=CC(O)=C(O)C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 326.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nishiyama S, Yamaguchi I, Akimoto Y, Yoshikawa M, Nakajima H. A novel orally active dopamine prodrug TA-870. II. Evidence that TA-870 is a dopamine prodrug. J Cardiovasc Pharmacol. 1989 Aug;14(2):175-83. doi: 10.1097/00005344-198908000-00001. PMID: 2476589. 2: Yoshikawa M, Endo H, Komatsu K, Fujihara M, Takaiti O, Kagoshima T, Umehara M, Ishikawa H. Disposition of a new orally active dopamine prodrug, N-(N-acetyl- L-methionyl)-O,O-bis(ethoxycarbonyl) dopamine (TA-870) in humans. Drug Metab Dispos. 1990 Mar-Apr;18(2):212-7. PMID: 1971575. 3: Yoshikawa M, Endo H, Komatsu K, Sugawara Y, Takaiti O. Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L- methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs. J Pharmacobiodyn. 1990 Apr;13(4):246-53. doi: 10.1248/bpb1978.13.246. PMID: 2384858. 4: Yoshikawa M, Endo H, Hoshino K, Sugawara Y, Takaiti O, Kanda S, Imai K. A new method for the high performance liquid chromatographic determination of TA-870, a dopamine prodrug (catechol ester compound). Biomed Chromatogr. 1990 Sep;4(5):181-7. doi: 10.1002/bmc.1130040503. PMID: 2279144. 5: Yoshikawa M, Nishiyama S, Endo H, Togo Y, Takaiti O. First pass metabolism and in vitro metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L- methionyl)-O,O-bis(ethoxycarbonyl)dopamine in dogs. Drug Metab Dispos. 1991 Sep- Oct;19(5):960-5. PMID: 1686243.