Fenobam is a a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam has been used as a lead compound for the development of a range of newer mGluR5 antagonists.
MedKoo Cat#: 127478
Name: Fenobam HCl
CAS#: Fenobam HCl
Chemical Formula: C11H12Cl2N4O2
Exact Mass: 302.0337
Molecular Weight: 303.14
Elemental Analysis: C, 43.58; H, 3.99; Cl, 23.39; N, 18.48; O, 10.56
The following data is based on the product molecular weight 303.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
-C12-2002525.jpg "(S)-C12-200")
