MedKoo Cat#: 150126 | Name: Potassium Estrone Sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. Estrone is known to be a carcinogen for human females as well as a cause of breast tenderness or pain, nausea, headache, hypertension, and leg cramps in the context of non-endogenous exposure. In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile dysfunction.

Chemical Structure

Potassium Estrone Sulfate
Potassium Estrone Sulfate
CAS#1240-04-6

Theoretical Analysis

MedKoo Cat#: 150126

Name: Potassium Estrone Sulfate

CAS#: 1240-04-6

Chemical Formula: C18H21KO5S

Exact Mass: 388.0750

Molecular Weight: 388.52

Elemental Analysis: C, 55.65; H, 5.45; K, 10.06; O, 20.59; S, 8.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
potassium estrone sulfate; Estrone sulfate (potassium); Estrone sulfate potassium;
IUPAC/Chemical Name
Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, potassium salt
InChi Key
CUQHOFAEIPGLBH-ZFINNJDLSA-M
InChi Code
1S/C18H22O5S.K/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,15-,16+,18+;/m1./s1
SMILES Code
C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=C(C=CC(OS(=O)([O-])=O)=C4)[C@@]3([H])CC1)C2=O.[K+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 388.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rezvanpour A, Don-Wauchope AC. Clinical implications of estrone sulfate measurement in laboratory medicine. Crit Rev Clin Lab Sci. 2017 Mar;54(2):73-86. doi: 10.1080/10408363.2016.1252310. Epub 2016 Dec 14. PMID: 27960570. 2: Bjerregaard-Olesen C, Ghisari M, Kjeldsen LS, Wielsøe M, Bonefeld-Jørgensen EC. Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor. Steroids. 2016 Jan;105:50-8. doi: 10.1016/j.steroids.2015.11.009. Epub 2015 Dec 5. PMID: 26666359. 3: Wehner G, Schweikert HU. Estrone sulfate source of estrone and estradiol formation in isolated human hair roots: identification of a pathway linked to hair growth phase and subject to site-, gender-, and age-related modulations. J Clin Endocrinol Metab. 2014 Apr;99(4):1393-9. doi: 10.1210/jc.2013-2607. Epub 2014 Jan 16. PMID: 24432990. 4: Li PK, Pillai R, Dibbelt L. Estrone sulfate analogs as estrone sulfatase inhibitors. Steroids. 1995 Mar;60(3):299-306. doi: 10.1016/0039-128x(94)00048-h. PMID: 7792836. 5: Macrina AL, Ott TL, Roberts RF, Kensinger RS. Estrone and estrone sulfate concentrations in milk and milk fractions. J Acad Nutr Diet. 2012 Jul;112(7):1088-93. doi: 10.1016/j.jand.2012.02.005. Epub 2012 May 5. PMID: 22561023.