Synonym
VU10010; VU 10010; VU-10010
IUPAC/Chemical Name
3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
InChi Key
FPRULFHDSFKYBV-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16ClN3OS/c1-9-7-10(2)21-17-13(9)14(19)15(23-17)16(22)20-8-11-3-5-12(18)6-4-11/h3-7H,8,19H2,1-2H3,(H,20,22)
SMILES Code
CC1=CC(=NC2=C1C(=C(S2)C(=O)NCC3=CC=C(C=C3)Cl)N)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
345.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE,
Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ. An allosteric potentiator
of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008
Jan;4(1):42-50. doi: 10.1038/nchembio.2007.55. Epub 2007 Dec 2. PMID: 18059262.
2: Brady AE, Jones CK, Bridges TM, Kennedy JP, Thompson AD, Heiman JU,
Breininger ML, Gentry PR, Yin H, Jadhav SB, Shirey JK, Conn PJ, Lindsley CW.
Centrally active allosteric potentiators of the M4 muscarinic acetylcholine
receptor reverse amphetamine-induced hyperlocomotor activity in rats. J
Pharmacol Exp Ther. 2008 Dec;327(3):941-53. doi: 10.1124/jpet.108.140350. Epub
2008 Sep 4. PMID: 18772318; PMCID: PMC2745822.
