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MedKoo Cat#: 150118 | Name: Dimethadione

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimethadione is the N-demethylated metabolite of the anticonvulsant trimethadione. Dimethadione is considered to be a blocker of T-type calcium channel.

Chemical Structure

Dimethadione
CAS#695-53-4

Theoretical Analysis

MedKoo Cat#: 150118

Name: Dimethadione

CAS#: 695-53-4

Chemical Formula: C5H7NO3

Exact Mass: 129.0430

Molecular Weight: 129.12

Elemental Analysis: C, 46.51; H, 5.46; N, 10.85; O, 37.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dimethadione; 5,5-Dimethyloxazolidine-2,4-dione; 5,5-Dimethyl-2,4-oxazolidinedione; Eupractone;
IUPAC/Chemical Name
5,5-dimethyl-1,3-oxazolidine-2,4-dione
InChi Key
JYJFNDQBESEHJQ-UHFFFAOYSA-N
InChi Code
1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)
SMILES Code
O=C(N1)OC(C)(C)C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 129.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Noda A, Okumura I, Ibuki E, Hotta S, Nomoto K, Miyamoto E, Takeuchi K, Watanabe T. Effect of dimethadione derived from repeated oral administration of trimethadione on pancreatic secretion in dogs. Gastroenterol Jpn. 1990 Oct;25(5):613-8. doi: 10.1007/BF02779362. PMID: 2227252. 2: Weston AD, Brown NA, Ozolinš TR. Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione. Birth Defects Res B Dev Reprod Toxicol. 2011 Jun;92(3):206-15. doi: 10.1002/bdrb.20302. Epub 2011 Jun 2. PMID: 21638752. 3: Buttar HS, Dupuis I, Khera KS. Dimethadione-induced fetotoxicity in rats. Toxicology. 1978 Feb;9(1-2):155-64. doi: 10.1016/0300-483x(78)90040-9. PMID: 653736.

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Benzyl-PEG8-acid

Benzyl-PEG8-acid