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MedKoo Cat#: 598653 | Name: Leyk

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leyk is a bioactive chemical.

Chemical Structure

Leyk
CAS#1950-36-3

Theoretical Analysis

MedKoo Cat#: 598653

Name: Leyk

CAS#: 1950-36-3

Chemical Formula: C13H17N3O4

Exact Mass: 279.1219

Molecular Weight: 279.30

Elemental Analysis: C, 55.91; H, 6.14; N, 15.05; O, 22.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Leyk; NSC 400257; NSC-400257; NSC400257; Leukogen; Leucogen;
IUPAC/Chemical Name
2-(2-ethoxy-2-oxo-1-phenylethyl)-1,2,3-triazolidine-4-carboxylic acid
InChi Key
VTEWQLLYCXLCRD-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H17N3O4/c1-2-20-13(19)11(9-6-4-3-5-7-9)16-14-8-10(15-16)12(17)18/h3-7,10-11,14-15H,2,8H2,1H3,(H,17,18)
SMILES Code
O=C(OCC)C(C1=CC=CC=C1)N2NCC(C(O)=O)N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Leyk is a bioactive chemical.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 279.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Eichhorn L, Leyk D. Diving medicine in clinical practice. Dtsch Arztebl Int. 2015 Feb 27;112(9):147-57; quiz 158. doi: 10.3238/arztebl.2015.0147. Review. PubMed PMID: 25797514; PubMed Central PMCID: PMC4381562. 2: Eichhorn L, Leyk D. In Reply. Dtsch Arztebl Int. 2015 Sep 11;112(37):614-5. doi: 10.3238/arztebl.2015.0614c. PubMed PMID: 26396052; PubMed Central PMCID: PMC4581114. 3: Maclaurin G, Leyk S, Hunter LM. Understanding the combined impacts of aggregation and spatial non-stationarity: The case of migration-environment associations in rural South Africa. Trans GIS. 2015 Dec;19(6):877-895. doi: 10.1111/tgis.12134. Epub 2015 Feb 27. PubMed PMID: 28190960; PubMed Central PMCID: PMC5298210. 4: Leyk D. Health maintenance and –promotion of civil and military personnel was and is of pivotal importance. Dtsch Arztebl Int. 2014 Oct 31;111(44):756. doi: 10.3238/arztebl.2014.0756. PubMed PMID: 25412635; PubMed Central PMCID: PMC4239583. 5: Rohde U, Sievert A, Rüther T, Witzki A, Leyk D. Concept for a Predeployment Assessment of Basic Military Fitness in the German Armed Forces. J Strength Cond Res. 2015 Nov;29 Suppl 11:S211-5. doi: 10.1519/JSC.0000000000001074. PubMed PMID: 26506190. 6: Glitz KJ, Seibel U, Rohde U, Gorges W, Witzki A, Piekarski C, Leyk D. Reducing heat stress under thermal insulation in protective clothing: microclimate cooling by a 'physiological' method. Ergonomics. 2015;58(8):1461-9. doi: 10.1080/00140139.2015.1013574. Epub 2015 Mar 4. PubMed PMID: 25679096. 7: Leyk J, Goldbaum O, Noack M, Richter-Landsberg C. Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J Mol Neurosci. 2015 Apr;55(4):1031-46. doi: 10.1007/s12031-014-0460-y. Epub 2014 Dec 2. PubMed PMID: 25434725. 8: Noack M, Leyk J, Richter-Landsberg C. HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. Glia. 2014 Apr;62(4):535-47. doi: 10.1002/glia.22624. Epub 2014 Jan 24. PubMed PMID: 24464872. 9: HARUNA H, SUZUKI S, OKUJIMA J, TAKANO T, OGISO A, HASHIMOTO S, MATSUBAYASHI Y, IZUMI K, KATAYAMA M. [THE EFFECT OF LEYK (CYSTEINE DERIVATIVE) ON THE RADIATION INJURY]. Nihon Igaku Hoshasen Gakkai Zasshi. 1963 Sep;23:685-97. Japanese. PubMed PMID: 14085593. 10: EZAKI H, FUNAOKA H. [EFFECTS OF LEYK FOR ROENTGEN DAMAGE IN MICE]. Nihon Igaku Hoshasen Gakkai Zasshi. 1963 Dec 25;23:1062-7. Japanese. PubMed PMID: 14101089. 11: Leyk D, Witzki A, Willi G, Rohde U, Rüther T. Even One Is Too Much: Sole Presence of One of the Risk Factors Overweight, Lack of Exercise, and Smoking Reduces Physical Fitness of Young Soldiers. J Strength Cond Res. 2015 Nov;29 Suppl 11:S199-203. doi: 10.1519/JSC.0000000000001067. PubMed PMID: 26506188. 12: Leyk M, Ksiaz˙ek J, Habel A, Dobosz M, Kruk A, Terech S. The influence of social support from the family on health related-quality of life in persons with a colostomy. J Wound Ostomy Continence Nurs. 2014 Nov-Dec;41(6):581-8. doi: 10.1097/WON.0000000000000086. PubMed PMID: 25377109. 13: Tatsuno I. [Effect of leyk on leukopenia induced by radiotherapy]. Rinsho Hoshasen. 1970 Nov;15(11):871-6. Japanese. PubMed PMID: 5203506. 14: Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, Calabresi P, Selmaj K, Agoropoulou C, Leyk M, Zhang-Auberson L, Burtin P; FREEDOMS Study Group. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010 Feb 4;362(5):387-401. doi: 10.1056/NEJMoa0909494. Epub 2010 Jan 20. PubMed PMID: 20089952. 15: Friedl KE, Breivik TJ, Carter R 3rd, Leyk D, Opstad PK, Taverniers J, Trousselard M. Soldier Health Habits and the Metabolically Optimized Brain. Mil Med. 2016 Nov;181(11):e1499-e1507. Review. PubMed PMID: 27849483. 16: Huang XE, Cao J, Qian ZY, Xu X, Shi L, Wu XY, Liu J, Wang L. Leucogen tablets at 60 mg three times per day are safe and effective to control febrile neutropenia. Asian Pac J Cancer Prev. 2014;15(19):8495-7. PubMed PMID: 25339053. 17: Leyk D, Rohde U, Hartmann ND, Preuß PA, Sievert A, Witzki A. Results of a workplace health campaign: what can be achieved? Dtsch Arztebl Int. 2014 May 2;111(18):320-7. doi: 10.3238/arztebl.2014.0320. PubMed PMID: 24861651; PubMed Central PMCID: PMC4038044. 18: Leyk G, Hirschfeld S, Böthig R, Willenbrock U, Thietje R, Lönnecker S, Stuhr M. [Spinal cord injury (SCI) - Aspects of intensive medical care]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2014 Sep;49(9):506-12; quiz 513. doi: 10.1055/s-0034-1390052. Epub 2014 Sep 19. German. PubMed PMID: 25238008. 19: Richter-Landsberg C, Leyk J. Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration. Acta Neuropathol. 2013 Dec;126(6):793-807. doi: 10.1007/s00401-013-1158-x. Epub 2013 Aug 3. Review. PubMed PMID: 23912309. 20: Malishkevich A, Leyk J, Goldbaum O, Richter-Landsberg C, Gozes I. ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment. J Mol Neurosci. 2015 Oct;57(2):304-13. doi: 10.1007/s12031-015-0640-4. PubMed PMID: 26315608.