DWP-05195 | CAS#904309-12-2 | TRPV1 antagonist

MedKoo Cat#: 145289 | Name: DWP-05195

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DWP-05195 is a TRPV1 antagonist. DWP05195 induces ER stress-induced apoptosis via the ROS-p38-CHOP pathway in human ovarian cancer cells. Studies show that DWP05195 can be used as a TRPV1 antagonist for pain management.

Chemical Structure

DWP-05195

CAS#904309-12-2

Theoretical Analysis

MedKoo Cat#: 145289

Name: DWP-05195

CAS#: 904309-12-2

Chemical Formula: C18H10BrF3N4

Exact Mass: 418.0041

Molecular Weight: 419.21

Elemental Analysis: C, 51.57; H, 4.20; Br, 19.06; F, 13.60; N, 13.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DWP-05195; DWP05195; DWP 05195;

IUPAC/Chemical Name

6-bromo-2-(3-(trifluoromethyl)-[2,3'-bipyridin]-6'-yl)-1H-benzo[d]imidazole

InChi Key

WGAVAOCYBMNWID-UHFFFAOYSA-N

InChi Code

1S/C18H10BrF3N4/c19-11-4-6-13-15(8-11)26-17(25-13)14-5-3-10(9-24-14)16-12(18(20,21)22)2-1-7-23-16/h1-9H,(H,25,26)

SMILES Code

FC(F)(F)C1=C(N=CC=C1)C2=CN=C(C=C2)C3=NC4=C(N3)C=C(Br)C=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 419.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang YY, Lee KT, Lim MC, Choi JH. TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells. Cancers (Basel). 2020 Jun 26;12(6):1702. doi: 10.3390/cancers12061702. PMID: 32604833; PMCID: PMC7352786. 2: Lee J, Kim BH, Yu KS, Kim HS, Kim JD, Cho JY, Lee S, Gu N. A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers. Drug Des Devel Ther. 2017 Apr 24;11:1301-1313. doi: 10.2147/DDDT.S128727. PMID: 28479852; PMCID: PMC5411174.