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MedKoo Cat#: 574279 | Name: (±)-β-Tocopherol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and inhibits LPS-induced COX-2 gene expression. Unlike (±)-α-tocopherol, (±)-β-tocopherol does not inhibit smooth muscle cell proliferation, decrease PKC activity, increase phosphoprotein phosphatase 2A (PP2A) activity, or modify expression of the α-tropomyosin gene.

Chemical Structure

(±)-β-Tocopherol
(±)-β-Tocopherol
CAS#148-03-8

Theoretical Analysis

MedKoo Cat#: 574279

Name: (±)-β-Tocopherol

CAS#: 148-03-8

Chemical Formula: C28H48O2

Exact Mass: 416.3654

Molecular Weight: 416.69

Elemental Analysis: C, 80.71; H, 11.61; O, 7.68

Price and Availability

Size Price Availability Quantity
50mg USD 550.00
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Related CAS #
No Data
Synonym
(±)-β-Tocopherol, DL-β-Tocopherol, rac-β-Tocopherol
IUPAC/Chemical Name
(2R)-rel-3,4-dihydro-2,5,8-trimethyl-2-[4R,8R,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
InChi Key
WGVKWNUPNGFDFJ-DQCZWYHMSA-N
InChi Code
InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-24(6)26(29)19-23(5)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28-/m1/s1
SMILES Code
CC1=C2C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C(C)C(O)=C1
Appearance
A solution in hexane
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 416.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lobato ADSM, Silva JARD, Rodrigues TCGC, Silva AGME, Cruz AVD, Ferreira APD, Costa MM, Cunha AMQ, Lourenço-Costa VV, Barbosa AVC, Prates JAM, Silva WCD, Lourenço-Júnior JB. Impact of Production Systems on the Levels of Vitamin E, β-Carotene, and Cholesterol in the Liver of Cattle Raised in the Eastern Amazon. Foods. 2024 May 21;13(11):1595. doi: 10.3390/foods13111595. PMID: 38890823; PMCID: PMC11172091. 2: Dos Santos Miranda Lobato A, da Silva JAR, de Carvalho Rodrigues TCG, Silva AGME, da Cruz AV, Ferreira APD, Costa MM, Cunha AMQ, Lourenço-Costa VV, Barbosa AVC, Prates JAM, de Brito Lourenço-Júnior J. Impact of rearing systems in the Eastern Amazon on cholesterol, β-carotene and vitamin E homologues in steer. Front Vet Sci. 2024 May 16;11:1331913. doi: 10.3389/fvets.2024.1331913. PMID: 38818497; PMCID: PMC11138155. 3: Kassem MA, Knizia D, Meksem K. A Summary of Two Decades of QTL and Candidate Genes That Control Seed Tocopherol Contents in Maize (Zea mays L.). Genes (Basel). 2024 Apr 9;15(4):472. doi: 10.3390/genes15040472. PMID: 38674406; PMCID: PMC11049817. 4: Pino JMV, Silva VF, Campos RMS, Mônico-Neto M, de Araujo KA, Seva DC, Kato MY, Galvão TD, Bitterncourt LRA, Tufik S, Lee KS. Impact of Bariatric Surgery on Circulating Metabolites and Cognitive Performance. Obes Surg. 2024 Apr;34(4):1102-1112. doi: 10.1007/s11695-024-07096-6. Epub 2024 Feb 16. PMID: 38363496. 5: Wu Z, Li Y, Qiu H, Long S, Zhao X, Wang Y, Guo X, Baitelenova A, Qiu C. Comparative Assessment of Lignan, Tocopherol, Tocotrienol and Carotenoids in 40 Selected Varieties of Flaxseed (Linum usitatissimum L.). Foods. 2023 Nov 24;12(23):4250. doi: 10.3390/foods12234250. PMID: 38231648; PMCID: PMC10706792. 6: Li M, Liu M, Wang X, Wei H, Jin S, Liu X. Comparison of intestinal microbes and metabolites in active VKH versus acute anterior uveitis associated with ankylosing spondylitis. Br J Ophthalmol. 2023 Oct 11:bjo-2023-324125. doi: 10.1136/bjo-2023-324125. Epub ahead of print. PMID: 37821210. 7: Ayadi N, Rayda Ben Ayed, Ercisli S, Durul MS, Sakar E, Rebai A. γ-tocopherol methyltransferase gene sequencing and SNP discovery associated with olive oil quality. Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):111-117. doi: 10.14715/cmb/2023.69.8.17. PMID: 37715410. 8: Hu L, Zhou Y, Wang J, Yang Z. Countercurrent chromatography separation of vitamin E isomers in a co-current mode. J Sep Sci. 2023 Nov;46(21):e2300285. doi: 10.1002/jssc.202300285. Epub 2023 Aug 31. PMID: 37654055. 9: Catzeddu P, Fois S, Tolu V, Sanna M, Braca A, Vitangeli I, Anedda R, Roggio T. Quality Evaluation of Fresh Pasta Fortified with Sourdough Containing Wheat Germ and Wholemeal Semolina. Foods. 2023 Jul 8;12(14):2641. doi: 10.3390/foods12142641. PMID: 37509733; PMCID: PMC10378388. 10: Kong L, Lin Y, Liang J, Hu X, Ashraf U, Guo X, Bai S. Dynamic Changes in Vitamin E Biosynthesis during Germination in Brown Rice (Oryza sativa L.). Foods. 2022 Oct 13;11(20):3200. doi: 10.3390/foods11203200. PMID: 37430949; PMCID: PMC9601386. 11: Andonova T, Muhovski Y, Apostolova E, Naimov S, Petkova Z, Teneva O, Antova G, Slavov I, Dimitrova-Dyulgerova I. Koelreuteria paniculata Seed Oil-A Rich Natural Source of Unsaturated Fatty Acids and Phytocompounds with DNA Protective Potential. Foods. 2023 Jun 1;12(11):2230. doi: 10.3390/foods12112230. PMID: 37297478; PMCID: PMC10252210. 12: Huang B, Zhang J, Wang M, Chen Q, Xu W, Zhang Z. [Determination of vitamin A, D and E in dishes by two-dimensional liquid chromatography]. Wei Sheng Yan Jiu. 2023 Mar;52(2):272-279. Chinese. doi: 10.19813/j.cnki.weishengyanjiu.2023.02.016. PMID: 37062691. 13: Özcan MM. A review on some properties of almond: ımpact of processing, fatty acids, polyphenols, nutrients, bioactive properties, and health aspects. J Food Sci Technol. 2023 May;60(5):1493-1504. doi: 10.1007/s13197-022-05398-0. Epub 2022 Feb 21. PMID: 37033309; PMCID: PMC10076465. 14: van Vliet S, Blair AD, Hite LM, Cloward J, Ward RE, Kruse C, van Wietmarchsen HA, van Eekeren N, Kronberg SL, Provenza FD. Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat. J Anim Sci Biotechnol. 2023 Apr 1;14(1):49. doi: 10.1186/s40104-023-00843-2. PMID: 37004100; PMCID: PMC10067211. 15: Teuku Husni TR, Darmawi D, Azwar A, Jamil KF. Bioactive phytoconstituents of ethanolic extract from Chromolaena odorata leaves interact with vascular endothelial growth factor and cyclooxygenase-2: A molecular docking study. J Adv Pharm Technol Res. 2023 Jan-Mar;14(1):29-33. doi: 10.4103/japtr.japtr_520_22. Epub 2023 Jan 20. PMID: 36950458; PMCID: PMC10026325. 16: Górnaś P, Lācis G, Mišina I, Ikase L. Tocopherols in Cultivated Apple Malus sp. Seeds: Composition, Variability and Specificity. Plants (Basel). 2023 Mar 3;12(5):1169. doi: 10.3390/plants12051169. PMID: 36904029; PMCID: PMC10007172. 17: Kostić M, Ivanov M, Fernandes Â, Calhelha RC, Glamočlija J, Barros L, Soković M, Ćirić A. A Comparative Study of Lactarius Mushrooms: Chemical Characterization, Antibacterial, Antibiofilm, Antioxidant and Cytotoxic Activity. J Fungi (Basel). 2023 Jan 3;9(1):70. doi: 10.3390/jof9010070. PMID: 36675891; PMCID: PMC9864295. 18: Dimić I, Pavlić B, Rakita S, Cvetanović Kljakić A, Zeković Z, Teslić N. Isolation of Cherry Seed Oil Using Conventional Techniques and Supercritical Fluid Extraction. Foods. 2022 Dec 20;12(1):11. doi: 10.3390/foods12010011. PMID: 36613227; PMCID: PMC9818375. 19: Tavadyan L, Martoyan S, Kocharyan G, Kamal-Eldin A. Kinetic modeling of the reversal of antioxidant potency of α-, β-, γ- and δ-tocopherols in methyl linoleate peroxidation. Food Chem. 2023 Apr 16;406:134866. doi: 10.1016/j.foodchem.2022.134866. Epub 2022 Nov 8. PMID: 36462359. 20: Li J, Cao L, Fang F, Shi H, Huang Q, Tan L, Duan Q, Feng Y. [Rapid determination of 10 fat-soluble vitamins in health foods by ultra performance convergence chromatography]. Se Pu. 2022 Dec;40(12):1136-1142. Chinese. doi: 10.3724/SP.J.1123.2022.02010. PMID: 36450354; PMCID: PMC9727746.